ArticleAnnals of Saudi medicine
Prevalence of congenital heart diseases in children with Down syndrome in Mansoura, Egypt: a retrospective descriptive study.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Patterns, survival, and mortality predictors in children with down syndrome and congenital heart disease in resource-limited settings: a follow-up study.BMC pediatrics · 2026Article
- Article
- Maternal Blood Group Is a Possible Predictor for Developing Congenital Heart Disease in Turkish Children with Down's Syndrome.Journal of pediatric genetics · 2024Article
- Prevalence and Patterns of Congenital Heart Defects and Other Major Non-Syndromic Congenital Anomalies Among Down Syndrome Patients: A Retrospective Study.International journal of general medicine · 2024Article
- Assessing the Frequency of Congenital Heart Diseases Among Children in Eastern Afghanistan.Pediatric health, medicine and therapeutics · 2024Article
- Prevalence of Echocardiographic Profile and Its Related Risk Factors in Congenital Heart Disease Patients; A Cross-Sectional Study.Galen medical journal · 2024Article
- Clinical Profile of Indian Children with Down Syndrome.Journal of pediatric genetics · 2023Article
- Psychological capital, quality of life, and well-being in mother caregivers of individuals with down syndrome.Frontiers in psychology · 2023Article
- Types and Distribution of Congenital Heart Defects in Pediatric Patients with Down's Syndrome: A Retrospective Study.Cureus · 2020Article
- Prevalence of congenital heart disease among patients with down syndrome in Southwestern Saudi Arabia.Annals of African medicineArticle
- Gender and its association with cardiac defects in down syndrome population at Children Hospital & Institute of Child Health, Lahore, Pakistan.Pakistan journal of medical sciencesArticle
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3 authors at 1 institution in 1 country.
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Abstract
backgroundThe pattern and risk factors for congenital heart diseases (CHD) in children with Down syndrome (DS) vary over time.
objectivesTo update knowledge of the prevalence, types, trends and associated factors for CHD in children with DS in the Egyptian Delta.
designA retrospective hospital record-based descriptive study.
settingA tertiary care center in Mansoura, Egypt during a period of 14 years from 2003 up to 2016. PATIENTS AND
methodsWe studied children with genetically proven DS. Relevant sociodemographic factors, medical history, clinical examination, karyotype and echocardiographic data were statistically analyzed.
main outcome measuresPrevalence, types and risk factors of CHD in DS.
resultsThe prevalence of overall, isolated and multiple CHD in 1720 children with DS were 36.9%, 29% and 8%, respectively. Isolated defects accounted for 78.4% of all CHD. Ventricular septal defect, atrioventricular septal defect and atrial septal defect were the most frequent isolated defects. There was a downward trend in the prevalence of overall CHD (from 56.2% to 25.0%) and isolated CHD (from 56.2% to 19.8%). The logistic regression model predicted 65.7% of CHD and revealed that passive maternal smoking, lack of folic acid/multivitamin supplementation and parental consanguinity were the independent predictors of CHD in children with DS with adjusted odds ratios of 1.9, 1.8 and 1.9, respectively.
conclusionMore than one-third of children with DS have CHD with ventricular septal defect, which is the most common. Avoidance of passive maternal smoking and consanguineous marriage together with maternal folic acid supplementation could contribute to further reduction of CHD in children with DS. LIMITATIONS: Single-center study and retrospective.
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