ArticleHeart (British Cardiac Society)2018
Leg lean mass correlates with exercise systemic output in young Fontan patients.
Article in Heart (British Cardiac Society), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Body composition in patients with Fontan physiology: a systematic review.European journal of pediatrics · 2023Pooled it
- Fontan Circulation Associated Organ Abnormalities Beyond the Heart, Lungs, Liver, and Gut: A Systematic Review.Frontiers in cardiovascular medicine · 2022Pooled it
- Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.Annals of biomedical engineering · 2020Trial
- Exercise Capacity, Endothelial Function, Muscle Mass, and Strength in Pediatric Patients With Fontan Circulation.CJC pediatric and congenital heart disease · 2026Article
- Augmenting Venous Return in Fontan Circulation: The Role of the Skeletal Muscle Pump and Implications for Mechanical Compression Devices-A Review of the Literature.Pediatric cardiology · 2026Review
- Protocol for non-invasive assessment of skeletal muscle structure and function in adolescents with single ventricle heart disease: a cross-sectional, case-control study.Frontiers in cardiovascular medicine · 2026Article
- Identifying Frailty and Its Risk Factors in Pediatric Patients with Fontan Physiology.Pediatric cardiology · 2025Article
- How to Evaluate and Adjust the Recommended Level of Physical Activity in Patients with Congenital Heart Diseases? A Practical Approach.Journal of clinical medicine · 2025Review
- A Comprehensive Evaluation of Thigh Mineral-Free Lean Mass Measures Using Dual Energy X-Ray Absorptiometry (DXA) in Young Children.Journal of imaging · 2025Article
- Hypoplastic left heart syndrome (HLHS) becomes of age: Assessing the young adult with HLHS including the neoaorta/aortic arch.International journal of cardiology. Congenital heart disease · 2025Review
- Paediatric dominant and non-dominant handgrip reference curves and the association with body composition.Annals of human biology · 2024Article
- Fontan-associated liver disease: the importance of multidisciplinary teamwork in its management.Frontiers in medicine · 2024Review
- Home-Based Resistance Training Programme in Fontan Patients: It Is Feasible, Safe, and Efficient.CJC pediatric and congenital heart disease · 2023Article
- Exercise Pathophysiology and Testing in Individuals With a Fontan Circulation.CJC pediatric and congenital heart disease · 2023Review
- Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients.American heart journal · 2023Article
- Peak Work Rate Increases With Lower Extremity-Focused Exercise Training in Adolescents With Fontan Circulation.Journal of the American Heart Association · 2022Article
- Exercise Capacity and Training Programs in Paediatric Fontan Patients: A Systematic Review.CJC pediatric and congenital heart disease · 2022Review
- Skeletal muscle deficits are associated with worse exercise performance in pediatric pulmonary hypertension.Frontiers in pediatrics · 2022Article
- Deficits in the Functional Muscle-Bone Unit in Youths with Fontan Physiology.The Journal of pediatrics · 2021Article
- Exercise Intolerance, Benefits, and Prescription for People Living With a Fontan Circulation: The Fontan Fitness Intervention Trial (F-FIT)-Rationale and Design.Frontiers in pediatrics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveWe previously described lower leg lean mass Z-scores (LLMZ) in Fontan patients associated with worse peak oxygen consumption on metabolic exercise testing. We hypothesised that LLMZ correlates with indexed systemic flow (Qsi) and cardiac index (CI) on exercise cardiac magnetic resonance (eCMR).
methodsThirteen patients had LLM measured by dual-energy X-ray absorptiometry within mean 40 (range 0-258) days of eCMR. LLM was converted to sex and race-specific Z-scores based on healthy reference data. Ventricular volumes and flow measurements of the ascending and descending (DAO) aorta and superior vena cava (SVC) were obtained by CMR at rest and just after supine ergometer exercise to a heart rate associated with anaerobic threshold on prior exercise test. Baseline and peak exercise measures of Qsi (SVC+DAO/BSA) and CI, as well as change in Qsi and CI with exercise, were compared with LLMZ by linear regression.
resultsLLMZ was not correlated with resting flows, stroke volume or CI. There was a strong linear correlation between LLMZ and change in both CI (r=0.77, p=0.002) and Qsi (r=0.73, p=0.005) from rest to exercise. There was also a significant correlation between LLMZ and Qsi at exercise (r=0.70, p=0.008). The correlation between LLMZ and CI at exercise did not reach significance (r=0.3, p=0.07).
conclusionsIn our cohort, there was a strong linear correlation between LLMZ and change in both CI and Qsi from rest to exercise, suggesting that Fontan patients with higher LLMZ may be better able to augment systemic output during exercise, improving performance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.