Evidence map›Paper›PMID 28988196›Full record

ArticleGut2018

The oral microbiota in colorectal cancer is distinctive and predictive.

Burkhardt Flemer, Ryan D Warren, Maurice P Barrett, Katryna Cisek, Anubhav Das, Ian B Jeffery, Eimear Hurley, Micheal O'Riordain, Fergus Shanahan, Paul W O'Toole

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 406 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
406citing papers in PubMed, 8 pooled it
37.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

406 citing papers in PubMed, 8 syntheses or guidelines pooled it, 660 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Gut microbes · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Quantification of EctopicInternational journal of molecular sciences · 2026
    Article
  19. Review
  20. Article

346 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Burkhardt FlemerAPC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.
Ryan D WarrenAPC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.
Maurice P BarrettAPC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.
Katryna Cisek4D Pharma Cork Ltd, Cork, Ireland.
Anubhav Das4D Pharma Cork Ltd, Cork, Ireland.
Ian B JefferyAPC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.
Eimear HurleySchools of Microbiology, University College Cork, National University of Ireland, Cork, Ireland.
Micheal O'RiordainDepartment of Medicine, University College Cork, National University of Ireland, Cork, Ireland.
Fergus ShanahanAPC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.
Paul W O'TooleAPC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.
National University of Ireland · IEUniversity College Cork · IEBon Secours Hospital Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsMicrobiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC.

methodsWe profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103).

resultsSeveral oral taxa were differentially abundant in CRC compared with controls, for example,

conclusionThe heterogeneity of CRC may relate to microbiota types that either predispose or provide resistance to the disease, and profiling the oral microbiome may offer an alternative screen for detecting CRC.

Indexed as

MicrobiotaAdultAgedCase-Control StudiesColonic PolypsColorectal NeoplasmsFecesFemaleHumansMaleMiddle AgedMouthSensitivity and Specificitycolonic bacteriacolorectal cancercolorectal cancer screeningdiettumour markers

Identifiers

PMID28988196
PMCPMC6204958
OpenAlexW2762906919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.