Trial reportArchives of disease in childhood. Fetal and neonatal edition2018
Effect of MRI on preterm infants and their families: a randomised trial with nested diagnostic and economic evaluation.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01049594 (Evaluation of MR Imaging to Predict Neurodevelopmental Impairment in Preterm Infants), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of MR Imaging to Predict Neurodevelopmental Impairment in Preterm Infants
Who cites it
47 citing papers in PubMed, 122 citations in OpenAlex.
- Trial
- 'We knew it was a totally at random thing': parents' experiences of being part of a neonatal trial.Trials · 2017Trial
- Associations between neonatal brain structure and neurodevelopmental outcomes following very preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction.Scientific reports · 2026Article
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Early predictors of late childhood behavioural outcomes following very preterm birth.Psychological medicine · 2025Article
- Cranial Ultrasonography-Standards in Diagnosis of Intraventricular Hemorrhage and Ventricular Dilatation in Premature Neonates.Children (Basel, Switzerland) · 2025Review
- Feasibility and Usability of Low-Field Magnetic Resonance Imaging for Pediatric Neuroimaging in Low- and Middle-Income Countries: A Qualitative Study.Medical devices (Auckland, N.Z.) · 2025Article
- Conceptual framework for data harmonisation in mental health using the International Classification of Functioning, Disability and Health: an example with the R2D2-MH consortium.BMJ mental health · 2024Article
- The development of neonatal neurointensive care.Pediatric research · 2024Review
- A Simple MRI Score Predicts Pathological General Movements in Very Preterm Infants with Brain Injury-Retrospective Cohort Study.Children (Basel, Switzerland) · 2024Article
- Point of care magnetic resonance neonatal neuroimaging applications and early imaging in infants under active therapeutic hypothermia: a perspective.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Role of Brain Elastography in the Neonatal Setting: State of the Art of Ultrasonographic Techniques and Future Perspectives.Children (Basel, Switzerland) · 2024Review
- Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China.Scientific data · 2024Article
- A prospective assessment of readiness to implement an early detection of cerebral palsy pathway in a neonatal intensive care setting using the PARIHS framework.Implementation science communications · 2024Article
- Distinct Neurodevelopmental Trajectories in Groups of Very Preterm Children Screening Positively for Autism Spectrum Conditions.Journal of autism and developmental disorders · 2024Article
- Neurodevelopmental Outcome and Neuroimaging of Very Low Birth Weight Infants from an Italian NICU Adopting the Family-Centered Care Model.Children (Basel, Switzerland) · 2023Article
- Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting.Children (Basel, Switzerland) · 2023Article
- Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks.Translational psychiatry · 2023Article
- Exploring cognitive, behavioral and autistic trait network topology in very preterm and term-born children.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWe tested the hypothesis that routine MRI would improve the care and well-being of preterm infants and their families.
designParallel-group randomised trial (1.1 allocation; intention-to-treat) with nested diagnostic and cost evaluations (EudraCT 2009-011602-42).
settingParticipants from 14 London hospitals, imaged at a single centre. PATIENTS: 511 infants born before 33 weeks gestation underwent both MRI and ultrasound around term. 255 were randomly allocated (siblings together) to receive only MRI results and 255 only ultrasound from a paediatrician unaware of unallocated results; one withdrew before allocation.
main outcome measuresMaternal anxiety, measured by the State-Trait Anxiety inventory (STAI) assessed in 206/214 mothers receiving MRI and 217/220 receiving ultrasound. Secondary outcomes included: prediction of neurodevelopment, health-related costs and quality of life.
resultsAfter MRI, STAI fell from 36.81 (95% CI 35.18 to 38.44) to 32.77 (95% CI 31.54 to 34.01), 31.87 (95% CI 30.63 to 33.12) and 31.82 (95% CI 30.65 to 33.00) at 14 days, 12 and 20 months, respectively. STAI fell less after ultrasound: from 37.59 (95% CI 36.00 to 39.18) to 33.97 (95% CI 32.78 to 35.17), 33.43 (95% CI 32.22 to 34.63) and 33.63 (95% CI 32.49 to 34.77), p=0.02. There were no differences in health-related quality of life. MRI predicted moderate or severe functional motor impairment at 20 months slightly better than ultrasound (area under the receiver operator characteristic curve (CI) 0.74; 0.66 to 0.83 vs 0.64; 0.56 to 0.72, p=0.01) but cost £315 (CI £295-£336) more per infant.
conclusionsMRI increased costs and provided only modest benefits.
trial registrationClinicalTrials.gov NCT01049594 https://clinicaltrials.gov/ct2/show/NCT01049594. EudraCT: EudraCT: 2009-011602-42 (https://www.clinicaltrialsregister.eu/).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.