Evidence map›Paper›PMID 28987837›Full record

SynthesisWorld neurosurgery2018

Physiologic Growth Hormone-Replacement Therapy and Craniopharyngioma Recurrence in Pediatric Patients: A Meta-Analysis.

Nawaf M Alotaibi, Nadia Noormohamed, David J Cote, Salman Alharthi, Joanne Doucette, Hasan A Zaidi, Rania A Mekary, Timothy R Smith

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Craniopharyngiomas: Surgery and Radiotherapy.Advances and technical standards in neurosurgery · 2022
    Article
  17. Review
  18. Review
  19. Clinical experience of growth hormone replacement for pediatric intracranial germ cell tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Article
  20. Incidental brain tumors in children: an international neurosurgical, oncological survey.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nawaf M AlotaibiDepartment of Pharmaceutical Business and Administrative Sciences, MCPHS University, Boston, Massachusetts, USA.
Nadia NoormohamedDepartment of Pharmaceutical Business and Administrative Sciences, MCPHS University, Boston, Massachusetts, USA.
David J CoteComputational Neurosciences Outcomes Center, Brigham and Women's Hospital Department of Neurosurgery, Harvard Medical School, Boston, USA. Electronic address: david_cote@hms.harvard.edu.
Salman AlharthiDepartment of Pharmaceutical Business and Administrative Sciences, MCPHS University, Boston, Massachusetts, USA.
Joanne DoucetteDepartment of Pharmaceutical Business and Administrative Sciences, MCPHS University, Boston, Massachusetts, USA.
Hasan A ZaidiComputational Neurosciences Outcomes Center, Brigham and Women's Hospital Department of Neurosurgery, Harvard Medical School, Boston, USA.
Rania A MekaryComputational Neurosciences Outcomes Center, Brigham and Women's Hospital Department of Neurosurgery, Harvard Medical School, Boston, USA; Department of Pharmaceutical Business and Administrative Sciences, MCPHS University, Boston, Massachusetts, USA.
Timothy R SmithComputational Neurosciences Outcomes Center, Brigham and Women's Hospital Department of Neurosurgery, Harvard Medical School, Boston, USA.
MCPHS University · USHarvard University · USBrigham and Women's Hospital · US

Funding

Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
NCI NIH HHS T32 CA009001
6 · The paper itself

Abstract

objectiveA systematic review and meta-analysis were conducted to examine the effect of growth hormone-replacement therapy (GHRT) on the recurrence of craniopharyngioma in children.

methodsPubMed, Embase, and Cochrane databases were searched through April 2017 for studies that evaluated the effect of GHRT on the recurrence of pediatric craniopharyngioma. Pooled effect estimates were calculated with fixed- and random-effects models.

resultsTen studies (n = 3487 patients) met all inclusion criteria, including 2 retrospective cohorts and 8 case series. Overall, 3436 pediatric patients were treated with GHRT after surgery and 51 were not. Using the fixed effect model, we found that the overall craniopharyngioma recurrence rate was lower among children who were treated by GHRT (10.9%; 95% confidence interval 9.80%-12.1%; I

conclusionsThis meta-analysis demonstrated a lower recurrence rate of craniopharyngioma among children treated with GHRT than those who were not.

Indexed as

Hormone Replacement TherapyChildCraniopharyngiomaHuman Growth HormoneHumansNeoplasm Recurrence, LocalPituitary NeoplasmsHuman Growth HormoneCraniopharyngiomaGrowth hormoneGrowth hormone–replacement therapyPediatricsRecurrence

Identifiers

PMID28987837
PMCPMC5729106
OpenAlexW2761850068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.