Evidence map›Paper›PMID 28987762›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2018

Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury.

Aline L Cortes, Sabrina R Gonsalez, Lilimar S Rioja, Simone S C Oliveira, André L S Santos, Minolfa C Prieto, Paulo A Melo, Lucienne S Lara

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Matrix metalloproteinases in kidney homeostasis and diseases: an update.American journal of physiology. Renal physiology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Triad NaInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Aline L CortesInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Sabrina R GonsalezInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Lilimar S RiojaDepartamento de Patologia e Laboratórios, Universidade do Estado do Rio de Janeiro, Brazil.
Simone S C OliveiraDepartamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
André L S SantosDepartamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Minolfa C PrietoDepartment of Physiology, School of Medicine, Tulane University School of Medicine, New Orleans, LA, USA; Tulane Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA, USA.
Paulo A MeloInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Lucienne S LaraInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: lara@icb.ufrj.br.
Universidade Federal do Rio de Janeiro · BRTulane University · USUniversidade do Estado do Rio de Janeiro · BR

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
PLEIOTROPIC EFFECTS OF PRORENIN RECEPOR IN COLLECTING DUCT AND INTRARENAL RAS ACTIVATIONR01DK104375 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI PRIETO, MINOLFA C · 2014 to 2018
$1.7M
NIDDK NIH HHS R01 DK104375NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Doxycycline (Dc) belongs to the tetracycline-class of antibiotics with demonstrated beneficial molecular effects in the brain and heart, mainly through matrix metalloproteinases inhibition (MMP). However, Dc protection of renal function has not been demonstrated. We determined whether low doses of Dc would prevent decreases in glomerular filtration rate (GFR) and maintain tubular Na

Indexed as

Acute Kidney InjuryAnimalsCytoprotectionDose-Response Relationship, DrugDoxycyclineGlomerular Filtration RateKidneyMaleRatsRats, WistarReperfusion InjuryDoxycyclineAcute kidney injury (AKI)FibrosisGlomerular filtrationMatrix metalloproteinases (MMP)Sodium-transport

Identifiers

PMID28987762
PMCPMC5705293
OpenAlexW2764123626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.