ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017
Treating locally advanced lung cancer with a 1.5T MR-Linac - Effects of the magnetic field and irradiation geometry on conventionally fractionated and isotoxic dose-escalated radiotherapy.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Adoption of Hybrid MRI-Linac Systems for the Treatment of Brain Tumors: A Systematic Review of the Current Literature Regarding Clinical and Technical Features.Technology in cancer research & treatmentPooled it
- MR-Guided Adaptive Radiotherapy in Lung Cancer: Current Landscape and Future Directions.Cancers · 2026Review
- Prone Breast Radiotherapy on the MR-Linac: A Technical Note on Skin-Couch Contact Dose Effects.Journal of medical radiation sciences · 2026Article
- Deep Learning-Based Cardiac Chamber Segmentation in Magnetic Resonance-Guided Adaptive Radiation Therapy.Advances in radiation oncology · 2025Article
- Real-Time Dose-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2025Review
- Feasibility of segmental total body irradiation (SegTBI) using a 1.5T MR-linac.Journal of applied clinical medical physics · 2025Article
- Intrafraction motion and impact of margin reduction for MR-Linac online adaptive radiotherapy for pancreatic cancer treatments.Journal of medical radiation sciences · 2025Article
- Current status and upcoming developments for online adaptive proton therapy enabling a closed feedback loop for near real-time adaptation.Frontiers in oncology · 2025Review
- Review
- Patient expectation and experience of MR-guided radiotherapy using a 1.5T MR-Linac.Technical innovations & patient support in radiation oncology · 2024Article
- Severe radiation-induced lymphopenia during concurrent chemoradiotherapy for stage III non-small cell lung cancer: external validation of two prediction models.Frontiers in oncology · 2023Article
- MRI-LINAC: A transformative technology in radiation oncology.Frontiers in oncology · 2023Review
- Dosimetric analysis of MR-LINAC treatment plans for salvage spine SBRT re-irradiation.Journal of applied clinical medical physics · 2022Article
- Brain stereotactic radiosurgery using MR-guided online adaptive planning for daily setup variation: An end-to-end test.Journal of applied clinical medical physics · 2022Article
- Development of patient-reported outcomes item set to evaluate acute treatment toxicity to pelvic online magnetic resonance-guided radiotherapy.Journal of patient-reported outcomes · 2021Article
- MRI-Guided Radiation Therapy.Advances in oncology · 2021Article
- Retrospective Planning Study of Patients with Superior Sulcus Tumours Comparing Pencil Beam Scanning Protons to Volumetric-Modulated Arc Therapy.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2021Article
- Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer.Frontiers in oncology · 2021Article
- A review of the role of MRI in diagnosis and treatment of early stage lung cancer.Clinical and translational radiation oncology · 2020Review
- Evaluation of MRI-derived surrogate signals to model respiratory motion.Biomedical physics & engineering express · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study investigates the feasibility and potential benefits of radiotherapy with a 1.5T MR-Linac for locally advanced non-small cell lung cancer (LA NSCLC) patients. MATERIAL AND
methodsTen patients with LA NSCLC were retrospectively re-planned six times: three treatment plans were created according to a protocol for conventionally fractionated radiotherapy and three treatment plans following guidelines for isotoxic target dose escalation. In each case, two plans were designed for the MR-Linac, either with standard (∼7mm) or reduced (∼3mm) planning target volume (PTV) margins, while one conventional linac plan was created with standard margins. Treatment plan quality was evaluated using dose-volume metrics or by quantifying dose escalation potential.
resultsAll generated treatment plans fulfilled their respective planning constraints. For conventionally fractionated treatments, MR-Linac plans with standard margins had slightly increased skin dose when compared to conventional linac plans. Using reduced margins alleviated this issue and decreased exposure of several other organs-at-risk (OAR). Reduced margins also enabled increased isotoxic target dose escalation.
conclusionIt is feasible to generate treatment plans for LA NSCLC patients on a 1.5T MR-Linac. Margin reduction, facilitated by an envisioned MRI-guided workflow, enables increased OAR sparing and isotoxic target dose escalation for the respective treatment approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.