ArticleJournal of food and drug analysis2017
Antihemolytic and antioxidant properties of pearl powder against 2,2'-azobis(2-amidinopropane) dihydrochloride-induced hemolysis and oxidative damage to erythrocyte membrane lipids and proteins.
Article in Journal of food and drug analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
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- Integrated Analysis of Pithecellobium dulce Leaf Fractions for Ex Vivo Antioxidant, DNA Damage Protective, and Afzelin-Mediated Anti-Inflammatory Potentials via In Vivo and In Silico Approaches.Oxidative medicine and cellular longevity · 2026Article
- Exploring bioactive peptides from Andean grains and their potential applications: a review.Frontiers in nutrition · 2026Review
- In Vitro Gastrointestinal Bioaccessibility of the Phenolic Fraction fromFoods (Basel, Switzerland) · 2025Article
- Neurogrit Gold Attenuates 6-OHDA-Induced Dopaminergic Neurodegeneration in Parkinson's Model of Caenorhabditis elegans by Reducing α-Synuclein Accumulation and Pink/Pdr-1 Driven Mitochondrial Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Non-hormone replacement therapy to overcome premature ovarian insufficiency: advances in natural products and stem cells targeting autophagy.Frontiers in endocrinology · 2025Review
- Antioxidant and Wound Healing Bioactive Potential of Extracts Obtained from Bark and Needles of Softwood Species.Antioxidants (Basel, Switzerland) · 2023Article
- Effect and mechanism of pearl on ovarian function of rats with premature ovarian failure induced by tripterygium glycosides.Journal of traditional and complementary medicine · 2023Article
- Effects of Carboxymethyl Modification on the Acidic Polysaccharides fromAntioxidants (Basel, Switzerland) · 2022Article
- New insights into geraniol's antihemolytic, anti-inflammatory, antioxidant, and anticoagulant potentials using a combined biological and in silico screening strategy.Inflammopharmacology · 2022Article
- Inhibitory Effect of Seawater Pearl Hydrolysate on UVA-Induced Photoaging of Human Skin Fibroblasts.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The Application of Pearls in Traditional Medicine of China and Their Chemical Constituents, Pharmacology, Toxicology, and Clinical Research.Frontiers in pharmacology · 2022Review
- Phytochemical Profile, Free Radical Scavenging and Anti-Inflammatory Properties ofMolecules (Basel, Switzerland) · 2021Article
- Efficacy of Water-Soluble Pearl Powder Components Extracted by a COMaterials (Basel, Switzerland) · 2021Article
- Pearl Powder-An Emerging Material for Biomedical Applications: A Review.Materials (Basel, Switzerland) · 2021Review
- Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Integrated Physiological and Transcriptomic Analyses Responses to Altitude Stress in Oat (Frontiers in genetics · 2021Article
- Extraction, Purification, Bioactivities and Application of Matrix Proteins From Pearl Powder and Nacre Powder: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- Copper(II) generates ROS and RNS, impairs antioxidant system and damages membrane and DNA in human blood cells.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pearl powder, a well-known traditional mineral medicine, is reported to be used for well-being and to treat several diseases from centuries in Taiwan and China. We investigated the in vitro antihemolytic and antioxidant properties of pearl powder that could protect erythrocytes against 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative damage to membrane proteins/lipids. Human erythrocytes were incubated with different concentrations of pearl powder (50-200 μg/mL) for 30 minutes and then exposed to AAPH for 2-6 hours. We found that AAPH alone time dependently increased the oxidative hemolysis of erythrocytes, while pearl powder pretreatment substantially inhibited the hemolysis in a concentration-/time-dependent manner. AAPH-induced oxidative damage to erythrocyte membrane lipids was evidenced by the elevated malondialdehyde (MDA) levels. However, pearl powder remarkably inhibited the malondialdehyde formation, and the 200 μg/mL concentration showed almost similar malondialdehyde values to the control. Furthermore, pearl powder suppressed the AAPH-induced high-molecular-weight protein formation and concomitantly increased the low-molecular-weight proteins in erythrocytes. Antioxidant potential that was measured as superoxide dismutase activity and glutathione content was significantly dropped by AAPH incubation, which suggests the vulnerability of erythrocytes to AAPH-induced oxidative stress. Noteworthy, erythrocytes pretreated with pearl powder showed restored superoxide dismutase activity and glutathione levels against AAPH-induced loss. Our findings conclude that pearl powder attenuate free radical-induced hemolysis and oxidative damage to erythrocyte membrane lipids/proteins. The potent antioxidant property of pearl powder may offer protection from free radical-related diseases.
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