Evidence map›Paper›PMID 28987271›Full record

ArticleEuropean journal of pharmacology2017

CO-independent modification of K

Guido Gessner, Nirakar Sahoo, Sandip M Swain, Gianna Hirth, Roland Schönherr, Ralf Mede, Matthias Westerhausen, Hans Henning Brewitz, Pascal Heimer, Diana Imhof and 2 more

Open access · greenAbstract read
In one paragraph

Article in European journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The Triple Crown: NO, CO, and HPharmacology & therapeutics · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. "CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. FeACS chemical biology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Guido GessnerCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena & Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Nirakar SahooCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena & Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Sandip M SwainCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena & Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Gianna HirthCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena & Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Roland SchönherrCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena & Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Ralf MedeInstitute of Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Jena, Germany.
Matthias WesterhausenInstitute of Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Jena, Germany.
Hans Henning BrewitzPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, Bonn, Germany.
Pascal HeimerPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, Bonn, Germany.
Diana ImhofPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, Bonn, Germany.
Toshinori HoshiDepartment of Physiology, University of Pennsylvania, Philadelphia, USA.
Stefan H HeinemannCenter for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena & Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany. Electronic address: Stefan.H.Heinemann@uni-jena.de.
Friedrich Schiller University Jena · DEUniversity of Bonn · DEJena University Hospital · DEUniversity of Pennsylvania · US

Funding

Mechanism of blood pressure lowering by fatty acid nutraceuticalsR01GM121375 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI HOSHI, TOSHINORI · 2017 to 2020
$2.3M
NIGMS NIH HHS R01 GM121375
6 · The paper itself

Abstract

Although toxic when inhaled in high concentrations, the gas carbon monoxide (CO) is endogenously produced in mammals, and various beneficial effects are reported. For potential medicinal applications and studying the molecular processes underlying the pharmacological action of CO, so-called CO-releasing molecules (CORMs), such as tricabonyldichlororuthenium(II) dimer (CORM-2), have been developed and widely used. Yet, it is not readily discriminated whether an observed effect of a CORM is caused by the released CO gas, the CORM itself, or any of its intermediate or final breakdown products. Focusing on Ca

Indexed as

Carbon MonoxideHEK293 CellsHistidineHumansHydrogen-Ion ConcentrationOrganometallic CompoundsPotassium ChannelsCarbon MonoxideHistidineOrganometallic CompoundsPotassium Channelstricarbonyldichlororuthenium (II) dimerCarbon monoxideCORM-2 (PubChem CID: 10951331)CORM-3 (PubChem CID: 91826084)HemeoxygenaseK(+) channelMetal carbonylPatch clampPotassium channel

Identifiers

PMID28987271
PMCPMC5662205
OpenAlexW2763637256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.