Evidence map›Paper›PMID 28986966›Full record

ArticleJournal of biomedical optics2017

Vertical-cavity surface-emitting laser sources for gigahertz-bandwidth, multiwavelength frequency-domain photon migration.

Thomas D O'Sullivan, Keunsik No, Alex Matlock, Robert V Warren, Brian Hill, Albert E Cerussi, Bruce J Tromberg

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas D O'SullivanUniversity of California Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Med, United States.
Keunsik NoInfit and Co. Inc., Seocho-gu, Seoul, Republic of Korea.
Alex MatlockUniversity of California Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Med, United States.
Robert V WarrenUniversity of California Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Med, United States.
Brian HillUniversity of California Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Med, United States.
Albert E CerussiUniversity of California Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Med, United States.
Bruce J TrombergUniversity of California Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Med, United States.
University of California, Irvine · US

Funding

CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
Developing DOSI Technology for Monitoring Response To Breast Cancer ChemotherapyR01CA142989 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2010 to 2017
$4.1M
Compact Swept Near-Infrared Light Source for Broadband Diffuse Optical Spectroscopic Imaging of Breast MalignanciesR44CA176848 · NCI · VIXAR, INC. · PI DUMMER, MATTHEW · 2016 to 2017
$1.4M
Compact swept Near-Infrared Light Source for Broadband Diffuse Optical SpectroscoR43CA176848 · NCI · VIXAR, INC. · PI DUMMER, MATTHEW · 2012 to 2012
$273k
NCATS NIH HHS TL1 TR001415NCI NIH HHS R01 CA142989NCI NIH HHS R43 CA176848NCI NIH HHS R44 CA176848NCI NIH HHS T32 CA009054NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

Frequency-domain photon migration (FDPM) uses modulated laser light to measure the bulk optical properties of turbid media and is increasingly applied for noninvasive functional medical imaging in the near-infrared. Although semiconductor edge-emitting laser diodes have been traditionally used as miniature light sources for this application, we show that vertical-cavity surface-emitting lasers (VCSELs) exhibit output power and modulation performance characteristics suitable for FDPM measurements of tissue optical properties at modulation frequencies exceeding 1 GHz. We also show that an array of multiple VCSEL devices can be coherently modulated at frequencies suitable for FDPM and can improve optical power. In addition, their small size and simple packaging make them an attractive choice as components in wearable sensors and clinical FDPM-based optical spectroscopy systems. We demonstrate the benefits of VCSEL technology by fabricating and testing a unique, compact VCSEL-based optical probe with an integrated avalanche photodiode. We demonstrate sensitivity of the VCSEL-based probe to subcutaneous tissue hemodynamics that was induced during an arterial cuff occlusion of the upper arm in a human subject.

Indexed as

HemodynamicsLasersArmDiagnostic ImagingEquipment DesignHumansLasers, SemiconductorLightOptics and PhotonicsPhantoms, ImagingPhotonsSpectroscopy, Near-Infraredbiomedical opticsbiophotonicslasersmedical imagingsensorsspectroscopy

Identifiers

PMID28986966
PMCPMC5629456
OpenAlexW2762188103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.