SynthesisMusculoskeletal surgery2018
Treatment strategies for central low-grade chondrosarcoma of long bones: a systematic review of the literature and meta-analysis.
Synthesis in Musculoskeletal surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review.Acta orthopaedica · 2020Pooled it
- Wait, scan and then? Exploring the long-term natural course of 119 low-grade central cartilaginous lesions of the long bones with MRI follow-up.European radiology · 2026Article
- Imaging findings and complications after curettage of atypical cartilaginous tumors in long bones: a retrospective single-center cohort study.Skeletal radiology · 2026Article
- Surgical Management of Chondrosarcoma of the T11 With The Aid of a 3D Printed Model: A Case Report With Review of Literature.Indian journal of orthopaedics · 2026Article
- Microwave ablation combined with curettage for low-grade chondrosarcomas in the extremities: a single-center study.BMC musculoskeletal disorders · 2025Article
- Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.Orthopaedic surgery · 2023Article
- Magnetic Resonance Imaging Features and Prognostic Indicators of Local Recurrence after Curettage and Cementation of Atypical Cartilaginous Tumour in the Appendicular Skeleton.Journal of clinical medicine · 2023Article
- Active surveillance of atypical cartilaginous tumours of bone: short term quality of life measurements.Journal of orthopaedic surgery and research · 2023Article
- Shared decision making: Does a decision aid support patients with an atypical cartilaginous tumor in making a decision about treatment.PEC innovation · 2022Article
- Intralesional curettage and cementation of low-grade chondrosarcomas of the appendicular skeleton: Long-term results from a single center.Acta orthopaedica et traumatologica turcica · 2022Article
- The influence of site on the incidence and diagnosis of solitary central cartilage tumours of the femur. A 21Journal of clinical orthopaedics and trauma · 2022Article
- Article
- Calcium acts as a central player in melatonin antitumor activity in sarcoma cells.Cellular oncology (Dordrecht, Netherlands) · 2022Article
- [Conventional epiphyseal chondrosarcoma of childhood and adolescence: a case report].Der Unfallchirurg · 2021Article
- Curettage and cryosurgery for enchondroma and atypical cartilaginous tumors of the long bones: Oncological results of a large series.Journal of surgical oncology · 2021Article
- MRI-histopathological correlation in paediatric conventional central chondrosarcoma: a report of 17 cases.Skeletal radiology · 2021Article
- The importance of MRI review following the diagnosis of atypical cartilaginous tumour using image-guided needle biopsy.Skeletal radiology · 2021Article
- Chondral tumours: discrepancy rate between needle biopsy and surgical histology.Skeletal radiology · 2020Article
- Thirty-Day Outcomes after Surgery for Primary Sarcomas of the Extremities: An Analysis of the NSQIP Database.Journal of oncology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The need for wide local excision (WLE) versus intralesional (IL) treatment of low-grade chondrosarcomas (CS) of the appendicular skeleton remains controversial. We sought to perform a systematic review and meta-analysis to compare different conventional types of surgical treatments for grade I CS in terms of: (1) rate of local recurrence (LR) and metastases, (2) functional outcome as measured by the Musculoskeletal Tumor Society (MSTS) score, (3) complication rate. Eighteen studies enrolling 695 patients met our criteria. Studies reported on WLE versus IL treatment (n = 7), and IL treatment with or without different adjuvants (N = 11). The LR rate was not significantly different between WLE and IL treatment (OR 2.31; 95% CI, 0.85-6.2; P = 0.1). On the contrary, complication rates were significantly lower in favor of IL treatment (OR 2.27; 95% CI, 0.07-0.72; P = 0.012). The mean reported MSTS score ranged from 21.8 to 28.2 for WLE and from 26.5 to 29.7 for IL treatment, with a significant difference in favor of IL treatment. IL treatment as an alternative to WLE does not greatly increase the risk of LR or metastasis and has lower complication rates with better functional scores. In light of the retrospective nature of the studies available, our findings should be interpreted with caution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.