Evidence map›Paper›PMID 28986681›Full record

ArticleArchives of virology2018

The construction and application of a cell line resistant to novel subgroup avian leukosis virus (ALV-K) infection.

Rao Mingzhang, Zhao Zijun, Yuan Lixia, Chen Jian, Feng Min, Zhang Jie, Liao Ming, Cao Weisheng

Open access · hybridAbstract read
In one paragraph

Article in Archives of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Avian Leukosis: Will We Be Able to Get Rid of It?Animals : an open access journal from MDPI · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rao MingzhangCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China.
Zhao ZijunCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China.
Yuan LixiaCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China.
Chen JianCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China.
Feng MinCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China.
Zhang JieCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China.
Liao MingCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China. mliao@scau.edu.cn.
Cao WeishengCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou, 510642, People's Republic of China. caoweish@scau.edu.cn.
South China Agricultural University · CN

Funding

National Natural Science Foundation of China 31672552Natural Science Foundation of Guangdong Province, China 2016A030313403Poultry Industry Technology System of Guangdong 2016LM1114the Key Program of Science and Technology Development of Guangdong Province, China 2015A020209145the Key Project of the Agricultural Ministry CARS-42-G09the National Key R&D Project 2016YFD0501606
6 · The paper itself

Abstract

A novel avian leukosis viruses (ALV) subgroup named ALV-K was recently isolated from Chinese indigenous chickens which is different from the subgroups (A to E and J) that have previously been reported to infect chickens. More and more ALV-K strains have recently been isolated from local breeds of Chinese chickens. However, there are no more effective diagnostic methods for ALV-K other than virus isolation followed by envelope gene sequencing and comparison. Viral infection can be blocked through expression of the viral receptor-binding protein. In this study, we have engineered a cell line, DF-1/K, that expresses ALV-K env protein and thereby confers resistance to ALV-K infection. DF-1/K can be used in combination with the ALV-K susceptible cell line DF-1 as a specific diagnostic tool for ALV-K and provides a good tool for further research into the molecular mechanisms of interaction between ALV-K env protein and the host cell receptor.

Indexed as

AnimalsAvian LeukosisAvian Leukosis VirusCell LineChickensFibroblastsGenetic EngineeringHumansPoultry DiseasesViral Envelope ProteinsViral Envelope Proteins

Identifiers

PMID28986681
PMCPMC5756289
OpenAlexW2761099710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.