ArticleNeurosurgical review2018
Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature.
Article in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- Primary cerebral melanoma of the frontal lobe: a case report and review of the literature.International journal of surgery case reports · 2026Article
- Amelanotic primary thalamic melanoma: a case report.BMC neurology · 2026Article
- Pigmented Peril: A fatal case of Primary intracranial melanoma in a paediatric patient.Radiology case reports · 2025Article
- Primary Diffuse Leptomeningeal Melanomatosis Leading to Raised Intracranial Pressure in a Pediatric Patient.Clinical case reports · 2025Article
- Article
- Review
- Suspected Primary Intracranial Melanoma with Widespread Distant Metastases in a Cat.Animals : an open access journal from MDPI · 2023Article
- Primary diffuse leptomeningeal melanomatosis: a challenging diagnosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Atypical primary malignant melanoma originating in the spinal canal: A case report and literature review.Oncology letters · 2023Article
- Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions.Case reports in oncological medicine · 2023Article
- An atypical primary malignant melanoma arising from the cervical nerve root: A case report and review of literture.World journal of clinical cases · 2022Article
- Novel Insights into Diagnosis, Biology and Treatment of Primary Diffuse Leptomeningeal Melanomatosis.Journal of personalized medicine · 2021Article
- Diagnosis of meningeal melanomatosis in a dog using magnetic resonance imaging and cerebrospinal fluid findings.The Journal of veterinary medical science · 2021Article
- Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report.Medicine · 2020Article
- Primary intramedullary malignant melanoma: can imaging lead to the correct diagnosis?The Journal of international medical research · 2020Article
- Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives.Cancers · 2020Review
- Pediatric primary diffuse leptomeningeal melanomatosis: Case report and review of the literature.Medicine · 2020Article
- Primary melanoma of leptomeninge in a patient with giant congenital melanocytic nevus.Anais brasileiros de dermatologiaArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptomeningeal melanomatosis is an extremely rare variant of primary central nervous system (CNS) melanoma and has a poor prognosis and no standard treatment. Primary CNS melanoma is derived from the melanocytes of the leptomeninges. Here, we describe a case of a 37-year-old male who visited our hospital due to worsening headaches. Characteristic imaging findings of this tumor type include hyper-dense lesions that are enhanced by contrast medium on computed tomography and hyper-intensity on T1-weighted magnetic resonance images and iso- to hypo-intensity on T2-weighted magnetic resonance images. Imaging of the CNS in our patient showed several lesions of this type. Pathological diagnosis and exclusion of systemic melanoma are required to confirm primary CNS malignant melanoma. Partial resection of the mass in the left temporal lobe of this patient was performed, and histological analysis showed pigmentation, melanin black-45 positivity, and BRAF mutation. Because no lesions were found outside the CNS following a thorough whole-body search, he was diagnosed with primary CNS malignant melanoma with leptomeningeal melanomatosis. He was treated with whole-brain radiation and the BRAF kinase inhibitor vemurafenib. His condition worsened, and he was given the anti-programmed cell death-1 antibody nivolumab as second-line therapy. This was also unsuccessful, and he died 5 months after treatment initiation. Further studies are needed to improve treatment and prognosis of this rare but serious disease.
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