ArticleEuropean radiology2018
Differentiation of benign and malignant solid pancreatic masses using magnetic resonance elastography with spin-echo echo planar imaging and three-dimensional inversion reconstruction: a prospective study.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Practical and clinical applications of pancreatic magnetic resonance elastography: a systematic review.Abdominal radiology (New York) · 2021Pooled it
- Biofabrication and artificial intelligence strategies for investigating solid- and fluid-pressure mechanobiology in pancreatic ductal adenocarcinoma.Cancer metastasis reviews · 2026Review
- Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- 3D vector MR elastography applications in small organs.Magnetic resonance imaging · 2024Review
- Magnetic resonance elastography-derived stiffness: potential imaging biomarker for differentiation of benign and malignant pancreatic masses.Abdominal radiology (New York) · 2023Article
- Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastroenterology · 2022Review
- Design, Construction, and Implementation of a Magnetic Resonance Elastography Actuator for Research Purposes.Current protocols · 2022Article
- Clinical utility of 3D magnetic resonance elastography in patients with biliary obstruction.European radiology · 2022Article
- Multi-frequency magnetic resonance elastography of the pancreas: measurement reproducibility and variance among healthy volunteers.Gastroenterology report · 2022Article
- Added Value of Tomoelastography for Characterization of Pancreatic Neuroendocrine Tumor Aggressiveness Based on Stiffness.Cancers · 2021Article
- Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis.Journal of clinical medicine · 2021Review
- Distinguishing pancreatic cancer and autoimmune pancreatitis with in vivo tomoelastography.European radiology · 2021Article
- Rectal Tumor Stiffness Quantified byFrontiers in oncology · 2021Article
- Radiomics Model Based on MR Images to Discriminate Pancreatic Ductal Adenocarcinoma and Mass-Forming Chronic Pancreatitis Lesions.Frontiers in oncology · 2021Article
- The Advance of Magnetic Resonance Elastography in Tumor Diagnosis.Frontiers in oncology · 2021Review
- Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers.Journal of magnetic resonance imaging : JMRI · 2020Article
- Artificial neural networks for magnetic resonance elastography stiffness estimation in inhomogeneous materials.Medical image analysis · 2020Article
- Translating preclinical MRI methods to clinical oncology.Journal of magnetic resonance imaging : JMRI · 2019Review
- Differentiation of chronic mass-forming pancreatitis from pancreatic ductal adenocarcinoma using contrast-enhanced computed tomography.Cancer management and research · 2019Article
- New and Emerging Applications of Magnetic Resonance Elastography of Other Abdominal Organs.Topics in magnetic resonance imaging : TMRI · 2018Review
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo determine the diagnostic performance of MR elastography (MRE) and compare it with serum CA19-9 in differentiating malignant from benign pancreatic masses, with emphasis on differentiating between pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP).
methodsWe performed a prospective, consecutive, 24-month study in 85 patients with solid pancreatic masses confirmed by histopathologic examinations. The mass stiffness and stiffness ratio (calculated as the ratio of mass stiffness to the parenchymal stiffness) were assessed. The diagnostic accuracy was analysed by calculating the area under the ROC curve (AUROC).
resultsThe final diagnosis included 54 malignant tumours (43 patients with PDAC) and 31 benign masses (24 patients with MFP). The stiffness ratio showed better diagnostic performance than the mass stiffness and serum CA19-9 for the differentiation between malignant and benign masses (AUC: 0.912 vs. 0.845 vs. 0.702; P = 0.026, P < 0.001) and, specifically, between PDAC and MFP (AUC: 0.955 vs. 0.882 vs. 0.745; P = 0.026, P = 0.003). The sensitivity, specificity, and accuracy of stiffness ratio for the differentiation of PDAC and MFP were all higher than 0.9.
conclusionsMRE presents an effective and quantitative strategy for non-invasive differentiation between PDAC and MFP based on their mechanical properties. KEY POINTS: • 3D MRE is useful for calculating stiffness of solid pancreatic tumours. • Stiffness ratio outperformed stiffness and CA19-9 for differentiating PDAC from MFP. • Incorporation of 3D MRE into a standard MRI protocol is recommended.
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