ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018
Risk factors and reasons for treatment abandonment among children with lymphoma in Malawi.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Determinants of delayed childhood cancer care in low- and middle-income countries: A systematic review.Pediatric blood & cancer · 2023Pooled it
- The magnitude and associated factors of childhood cancer treatment abandonment at the university of Gondar comprehensive specialized hospital, Ethiopia.Scientific reports · 2025Article
- High-Dose Methotrexate Usage Without Drug-Level Monitoring in Advanced Pediatric Mature B-Cell Non-Hodgkin Lymphoma in a Resource-Limited Setting in Malawi.JCO global oncology · 2025Article
- Self-Perceived Barriers to Pediatric Cancer Care in Sub-Saharan Africa: A Cross-Sectional Multinational Study.JCO global oncology · 2025Article
- Sex Bias in Treatment Abandonment of Childhood Cancer in India.Indian journal of pediatrics · 2024Article
- Epidemiological trends and treatment abandonment of paediatric solid tumours in a nigerian tertiary hospital: a seven-year review (2016-2022).BMC cancer · 2024Article
- Response-Based Approach for Pediatric Hodgkin Lymphoma in Nations with Restricted Resources.International journal of hematology-oncology and stem cell research · 2024Article
- Experiences of caregivers of children with cancer in Malawi: A qualitative study.Cancer medicine · 2024Article
- Outcomes of Wilms tumor therapy in Lilongwe, Malawi, 2016-2021: Successes and ongoing research priorities.Pediatric blood & cancer · 2023Article
- The meaning of caring for patients with cancer among traditional medicine practitioners in Uganda: A grounded theory approach.PLOS global public health · 2023Article
- Implementation and Evaluation of Educational Videos to Improve Cancer Knowledge and Patient Empowerment.JCO global oncology · 2022Article
- Caregiver Acceptability of Mobile Phone Use for Pediatric Cancer Care in Tanzania: Cross-sectional Questionnaire Study.JMIR pediatrics and parenting · 2021Article
- Palliative care and catastrophic costs in Malawi after a diagnosis of advanced cancer: a prospective cohort study.The Lancet. Global health · 2021Article
- Pediatric lymphoma patients in Malawi present with poor health-related quality of life at diagnosis and improve throughout treatment and follow-up across all Pediatric PROMIS-25 domains.Pediatric blood & cancer · 2021Article
- Implementing Patient-Directed Cancer Education Materials Across Nigeria.JCO global oncology · 2021Article
- Feasibility of upfront mobile money transfers for transportation reimbursement to promote retention among patients receiving lymphoma treatment in Malawi.International health · 2021Article
- Study protocol for a single-centre observational study of household wellbeing and poverty status following a diagnosis of advanced cancer in Blantyre, Malawi -Wellcome open research · 2020Article
- Developing a Symptom Toolkit for Adult Lymphoma Patients Receiving Chemotherapy in Malawi.Palliative medicine reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
purposeLymphoma is the commonest pediatric cancer in sub-Saharan Africa (SSA). Frequent treatment abandonment contributes to suboptimal outcomes. We examined risk factors and reasons for treatment abandonment for this population in Malawi.
methodsWe conducted a mixed methods study among children < 18 years old with newly diagnosed lymphoma, prospectively enrolled during 2013-2016. All children received standardized diagnosis and treatment, and were followed for up to 2 years. Treatment abandonment was defined as failure to attend prescribed chemotherapy within 4 weeks, or post-treatment visit within 3 months. Child, guardian, and household characteristics associated with treatment abandonment were assessed. Semi-structured interviews were conducted with primary caregivers of children experiencing treatment abandonment.
resultsOf 121 children with newly diagnosed lymphoma, 72 (60%) had complete information regarding child, guardian, and household characteristics. Of these, 56 (78%) had Burkitt's and 16 (22%) Hodgkin's lymphoma. Forty-nine (68%) were male, median age was 10.6 years (interquartile range [IQR] 7.9-13.0), and 26 (36%) experienced treatment abandonment. Lack of guardian education and travel time ≥ 4 h to clinic were independently associated with treatment abandonment, with adjusted hazard ratio (aHR) 3.8 [95% confidence interval (CI) 1.5-8.9, p = 0.005] and aHR 2.9 (95% CI 1.2-6.9, p = 0.019), respectively. Commonest reasons for treatment abandonment endorsed by 15 guardians were community influence, suboptimal clinic environment, logistical challenges, transport costs, treatment toxicities, loss of hope, alternative healers, and beliefs about cure.
conclusionsThese findings highlight families at risk for treatment abandonment, underlying reasons, and opportunities to improve retention in care for pediatric cancer patients in SSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.