ArticleEuropean radiology2018
Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Formulation of Topical Dosage Forms Containing Synthetic and Natural Anti-Inflammatory Agents for the Treatment of Rheumatoid Arthritis.Molecules (Basel, Switzerland) · 2020Trial
- AOZORA study: 3-year interim analysis of safety and joint health in pediatric people with hemophilia A receiving emicizumab prophylaxis.Research and practice in thrombosis and haemostasis · 2025Article
- MRI features distinguishing pediatric Lyme arthritis from septic arthritis.Skeletal radiology · 2025Article
- Knee-ultrasound: reference values for the amount of joint fluid and synovial appearances in healthy children and adolescents.Pediatric radiology · 2025Article
- Measuring synovial thickness on knee MRI in pediatric patients with arthritis: is contrast necessary?Pediatric radiology · 2024Article
- Fluid-attenuated inversion-recovery sequence with fat suppression as an alternative to contrast-enhanced MRI in pediatric synovitis.Pediatric radiology · 2024Article
- Preliminary MRI-based investigation of characteristics and prognosis of knee bone marrow edema in children with juvenile idiopathic arthritis.Clinical rheumatology · 2022Article
- Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Imaging assessment of children presenting with suspected or known juvenile idiopathic arthritis: ESSR-ESPR points to consider.European radiology · 2020Review
- Exploring contrast-enhanced MRI findings of the clinically non-inflamed symptomatic pediatric wrist.Pediatric radiology · 2020Article
- Evaluation of Periarticular Soft Tissues in Patients With Juvenile Idiopathic Arthritis by Superb Microvascular Imaging and Shear Wave Elastography.Archives of rheumatology · 2020Article
- Review
- Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?Pediatric rheumatology online journal · 2019Article
- MRI of synovitis and joint fluid.Journal of magnetic resonance imaging : JMRI · 2019Review
- Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis.Pediatric radiology · 2019Article
- Imaging of the knee in juvenile idiopathic arthritis.Pediatric radiology · 2018Review
- Juvenile idiopathic arthritis: magnetic resonance imaging of the clinically unaffected knee.Pediatric radiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo define normative standards for the knee in healthy children using contrast-enhanced MRI, focusing on normal synovial membrane thickness. Secondly, presence of joint fluid and bone marrow oedema was evaluated.
methodsFor this study, children without disorders potentially resulting in (accompanying) arthritis were included. Patients underwent clinical assessments, followed by contrast-enhanced MRI. MRI features were evaluated in consensus using the Juvenile Arthritis MRI Scoring (JAMRIS) system. Additionally, the presence of joint fluid was evaluated. No cartilage lesions or bone abnormalities were observed.
resultsWe included 57 healthy children. The overall mean thickness of the normal synovial membrane was 0.4 mm (min-max; 0.0-1.8mm). The synovium was thickest around the cruciate ligaments and retropatellar and suprapatellar regions. The mean overall diameter of the largest pocket of joint fluid was 2.8 mm (min-max; 0.9-8.0mm). Bone marrow changes were observed in three children (all in the apex patellae).
conclusionsThe normal synovial membrane was maximally 1.8 mm thick, indicating that the JAMRIS cut-off value of 2 mm can be considered a valid measure for evaluating synovial hypertrophy. Some joint fluid and bone marrow changes suggestive of bone marrow oedema in the apex patellae can be seen in healthy children. KEY POINTS: • Knowledge on the normal synovial appearance using contrast-enhanced MR is lacking. • In healthy children, normal synovial membrane is maximally 1.8 mm thick. • Normal synovium is thickest around the cruciate ligaments, retropatellar and suprapatellar. • Bone marrow oedema in the apex patellae is seen in healthy children.
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