Evidence map›Paper›PMID 28986619›Full record

ArticleDer Orthopade2017

[Therapeutic utilization of stem cells in orthopedics].

C Chiari, S Walzer, D Stelzeneder, M Schreiner, R Windhager

Erratum issued Registry-linked trialOpen access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Der Orthopade, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05747469 (Use of Allograft Adipose Matrix for Small Joint Arthritis of the Hand), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05747469 early_phase1active not recruitingnot on this mapstarted 2023, after this paper: background citation

Use of Allograft Adipose Matrix for Small Joint Arthritis of the Hand

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2023 to 2027Enrolled34ConditionsOsteoarthritis HandArmslocal anaesthetic injection, Human Adipose Allograft
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Biologic principles of minced cartilage implantation: a narrative review.Archives of orthopaedic and trauma surgery · 2023
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

C ChiariUniversitätsklinik für Orthopädie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. catharina.chiari@meduniwien.ac.at.
S WalzerUniversitätsklinik für Orthopädie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
D StelzenederUniversitätsklinik für Orthopädie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
M SchreinerUniversitätsklinik für Orthopädie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
R WindhagerUniversitätsklinik für Orthopädie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
Medical University of Vienna · ATUniversitätszahnklinik Wien · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells are becoming increasingly more important in the field of regenerative medicine. Adult mesenchymal stem cells (MSCs) are harvested predominantly from bone marrow or adipose tissue, are already being used in the clinical setting and have a low potential for side effects. In orthopedics, experience has been gained in the treatment of bone defects, non-unions, cartilage defects, osteoarthritis and tendon pathologies. The current data are derived from case studies and randomized controlled trials are missing; therefore, there are many open questions concerning the optimal cell source, number of cells, administration technique (e.g. injections and matrices) or combinations with growth factors; however, it is evident from the data that MSCs have a positive effect on tissue regeneration and are safe to use.

Indexed as

Bone and BonesCartilageFractures, UnunitedHumansMesenchymal Stem Cell TransplantationOrthopedic ProceduresOsteoarthritisRegenerative MedicineTendinopathyTissue and Organ HarvestingBoneCartilageOsteoarthritisRegenerative medicineTendons

Identifiers

PMID28986619
OpenAlexW2763891253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.