Evidence map›Paper›PMID 28986608›Full record

ArticlePsychopharmacology2017

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).

Walter Francesconi, Attila Szücs, Fulvia Berton, George F Koob, Leandro F Vendruscolo, Pietro Paolo Sanna

Abstract read
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In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Gene coexpression patterns predict opiate-induced brain-state transitions.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Walter FrancesconiDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Attila SzücsBioCircuits Institute, University of California San Diego, La Jolla, CA, USA.
Fulvia BertonDepartment of Anatomy and Cell Biology, School of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
George F KoobDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Leandro F VendruscoloDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Pietro Paolo SannaDepartment of Immunology and Microbiology and Department ofNeuroscience, The Scripps Research Institute, La Jolla, CA, USA. psanna@scripps.edu.ORCID http://orcid.org/0000-0002-8307-2151
Scripps Research Institute · USEötvös Loránd University · HUUniversity of Pisa · IT

Funding

Neural substrates of opiate-HIV interactions.R01DA043268 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI SANNA, PIETRO P · 2016 to 2020
$2.9M
Homeostatic Plasticity in the BNST and Drug AbuseR01DA031566 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI SANNA, PIETRO P · 2011 to 2015
$1.9M
Cocaine abuse and plasticity in the lateral hypothalamusR21DA040458 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI SANNA, PIETRO P · 2015 to 2016
$472k
Hungarian National Brain Research Program KTIA_NAP_13-2014-0018National Institute on Drug Abuse DA031566National Institute on Drug Abuse DA043268NIDA NIH HHS R01 DA031566NIDA NIH HHS R01 DA043268NIDA NIH HHS R21 DA040458
6 · The paper itself

Abstract

rationaleDrugs of abuse can alter circuit dynamics by modifying synaptic efficacy and/or the intrinsic membrane properties of neurons. The juxtacapsular subdivision of the bed nucleus of stria terminalis (jcBNST) has unique connectivity that positions it to integrate cortical and amygdala inputs and provide feed-forward inhibition to the central nucleus of the amygdala (CeA), among other regions. In this study, we investigated changes in the synaptic and intrinsic properties of neurons in the rat jcBNST during protracted withdrawal from morphine dependence using a combination of conventional electrophysiological methods and the dynamic clamp technique.

resultsA history of opiate dependence induced a form of cell type-specific plasticity characterized by reduced inward rectification associated with more depolarized resting membrane potentials and increased membrane resistance. This cell type also showed a lower rheobase when stimulated with direct current (DC) pulses as well as a decreased firing threshold under simulated synaptic bombardment with the dynamic clamp. Morphine dependence also decreased excitatory postsynaptic potential amplification, suggesting the downregulation of the persistent Na

conclusionThese findings show that a history of morphine dependence leads to persistent cell type-specific plasticity of the passive membrane properties of a jcBNST neuronal population, leading to an overall increased excitability of such neurons. By altering the activity of extended amygdala circuits where they are embedded, changes in the integration properties of jcBNST neurons may contribute to emotional dysregulation associated with drug dependence and withdrawal.

Indexed as

AnimalsExcitatory Postsynaptic PotentialsMaleNeuronal PlasticityNeuronsOpioid-Related DisordersOrgan Culture TechniquesRatsRats, Sprague-DawleySeptal NucleiSynapsesSynaptic TransmissionDynamic clampOpiatesPhysiological propertiesSynaptic integration

Identifiers

PMID28986608
PMCPMC5993421
OpenAlexW2761328036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.