ArticleScientific reports2017
Parvalbumin-expressing interneurons can act solo while somatostatin-expressing interneurons act in chorus in most cases on cortical pyramidal cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
- Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.bioRxiv : the preprint server for biology · 2025Article
- Spike reliability is cell type specific and shapes excitation and inhibition in the cortex.Scientific reports · 2025Article
- Article
- Somatostatin-Positive Interneurons Contribute to Seizures inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Information Capacity of a Stochastically Responding Neuron Assembly.Neurocomputing · 2021Article
- Cortical Excitation:Inhibition Imbalance Causes Abnormal Brain Network Dynamics as Observed in Neurodevelopmental Disorders.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology.Frontiers in neuroscience · 2020Review
- Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents.Frontiers in neural circuits · 2020Review
- Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex.Frontiers in cellular neuroscience · 2020Article
- Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice.Scientific reports · 2019Article
- Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons.Nature communications · 2019Article
- Inhibitory Units: An Organizing Nidus for Feature-Selective SubNetworks in Area V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice.eLife · 2018Article
- Electrophysiological Profiling of Neocortical Neural Subtypes: A Semi-Supervised Method Applied toFrontiers in neuroscience · 2018Article
- Investigating the Serotonergic Modulation of Orientation Tuning of Neurons in Primary Visual Cortex of Anesthetized Mice.Basic and clinical neuroscienceArticle
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural circuits in the cerebral cortex consist primarily of excitatory pyramidal (Pyr) cells and inhibitory interneurons. Interneurons are divided into several subtypes, in which the two major groups are those expressing parvalbumin (PV) or somatostatin (SOM). These subtypes of interneurons are reported to play distinct roles in tuning and/or gain of visual response of pyramidal cells in the visual cortex. It remains unclear whether there is any quantitative and functional difference between the PV → Pyr and SOM → Pyr connections. We compared unitary inhibitory postsynaptic currents (uIPSCs) evoked by electrophysiological activation of single presynaptic interneurons with population IPSCs evoked by photo-activation of a mass of interneurons in vivo and in vitro in transgenic mice in which PV or SOM neurons expressed channelrhodopsin-2, and found that at least about 14 PV neurons made strong connections with a postsynaptic Pyr cell while a much larger number of SOM neurons made weak connections. Activation or suppression of single PV neurons modified visual responses of postsynaptic Pyr cells in 6 of 7 pairs whereas that of single SOM neurons showed no significant modification in 8 of 11 pairs, suggesting that PV neurons can act solo whereas most of SOM neurons may act in chorus on Pyr cells.
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