Evidence map›Paper›PMID 28986566›Full record

SynthesisScientific reports2017

Association between MGMT Promoter Methylation and Risk of Breast and Gynecologic Cancers: A Systematic Review and Meta-Analysis.

Ru Chen, Yonglan Zheng, Lin Zhuo, Shengfeng Wang

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Genetic and epigenetic landscape of OExploration of targeted anti-tumor therapy · 2025
    Review
  4. ConstitutionalInternational journal of molecular sciences · 2024
    Article
  5. Article
  6. Journal of clinical medicine · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ru ChenNational Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yonglan ZhengDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Lin ZhuoDepartment of Epidemiology & Bio-statistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Shengfeng WangDepartment of Epidemiology & Bio-statistics, School of Public Health, Peking University Health Science Center, Beijing, China. shengfengwang456@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of the promoter methylation of O

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseasePromoter Regions, GeneticDNA MethylationDNA Modification MethylasesDNA Repair EnzymesFemaleGenital Neoplasms, FemaleHumansPublication BiasRisk FactorsTumor Suppressor ProteinsDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTumor Suppressor Proteins

Identifiers

PMID28986566
PMCPMC5630583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.