ArticleScientific reports2017
Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Pooled it
- Repeated restraint stress enhances visual plasticity through locus coeruleus (LC)-V1 projection in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction.Schizophrenia (Heidelberg, Germany) · 2026Article
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- Age-dependent brain subcortical white and gray matter disruptions in patients with posttraumatic stress disorder.Anatomy & cell biology · 2025Article
- The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Review
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Childhood adversity, stress reactivity, and structural brain measures in stress-related/neurodevelopmental disorders, and their comorbidity: A large transdiagnostic cross-sectional study.Human brain mapping · 2024Article
- Repeated exposure to multiple concurrent stressors alters visual processing in the adult posterior parietal cortex.Neurobiology of stress · 2024Article
- Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry.Scientific reports · 2024Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- Impact of dietary changes on retinal neuronal plasticity in rodent models of physical and psychological trauma.Frontiers in genetics · 2024Article
- Post-traumatic Stress Disorder: Focus on Neuroinflammation.Molecular neurobiology · 2023Review
- Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Association of age of adverse childhood experiences with thalamic volumes and post-traumatic stress disorder in adulthood.Frontiers in behavioral neuroscience · 2023Article
- Understanding the relationships between physiological and psychosocial stress, cortisol and cognition.Frontiers in endocrinology · 2023Review
- FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents.Brain structure & function · 2022Article
- Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.Translational psychiatry · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychological stress induces many diseases including post-traumatic stress disorder (PTSD); however, the causal relationship between stress and brain atrophy has not been clarified. Applying single-prolonged stress (SPS) to explore the global effect of severe stress, we performed brain magnetic resonance imaging (MRI) acquisition and Voxel-based morphometry (VBM). Significant atrophy was detected in the bilateral thalamus and right visual cortex. Fluorescent immunohistochemistry for Iba-1 as the marker of activated microglia indicates regional microglial activation as stress-reaction in these atrophic areas. These data certify the impact of severe psychological stress on the atrophy of the visual cortex and the thalamus. Unexpectedly, these results are similar to chronic neuropathic pain rather than PTSD clinical research. We believe that some sensitisation mechanism from severe stress-induced atrophy in the visual cortex and thalamus, and the functional defect of the visual system may be a potential therapeutic target for stress-related diseases.
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