Evidence map›Paper›PMID 28986515›Full record

Trial reportBMJ quality & safety2018

Improving admission medication reconciliation with pharmacists or pharmacy technicians in the emergency department: a randomised controlled trial.

Joshua M Pevnick, Caroline Nguyen, Cynthia A Jackevicius, Katherine A Palmer, Rita Shane, Galen Cook-Wiens, Andre Rogatko, Mackenzie Bear, Olga Rosen, David Seki and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ quality & safety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02026453 (Pharmacists and Pharmacy Technicians to Improve Admission Medication History Accuracy), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02026453 nacompletednot on this map

Pharmacists and Pharmacy Technicians to Improve Admission Medication History Accuracy

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2014 to 2016Enrolled306ConditionsAdverse Drug EventsArmsPharmacist obtains admission medication history, Pharmacy technician obtains admission medication history
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Reducing medication errors for adults in hospital settings.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Pharmacist services for non-hospitalised patients.The Cochrane database of systematic reviews · 2018
    Pooled it
  4. Impact of medication reconciliation for improving transitions of care.The Cochrane database of systematic reviews · 2018
    Pooled it
  5. Engaging hospital patients in the medication reconciliation process using tablet computers.Journal of the American Medical Informatics Association : JAMIA · 2018
    Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. [Ward-based clinical pharmacists in intensive care medicine: an economic evaluation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024
    Article
  12. Article
  13. Article
  14. Enhancing healthcare access for an older population: The age-friendly emergency department.Journal of the American College of Emergency Physicians open · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Implementation of a Pharmacist-Managed Transitions of Care Tool.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joshua M PevnickDepartment of Medicine, Division of General Internal Medicine, Cedars-Sinai Health System, Los Angeles, California, USA.
Caroline NguyenDepartment of Pharmacy Services, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Cynthia A JackeviciusDepartment of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.
Katherine A PalmerDepartment of Pharmacy Services, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Rita ShaneDepartment of Pharmacy Services, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Galen Cook-WiensDepartment of Biomedical Sciences, Biostatistics and Bioinformatics Research Center, Cedars-Sinai Health System, Los Angeles, California, USA.
Andre RogatkoDepartment of Biomedical Sciences, Biostatistics and Bioinformatics Research Center, Cedars-Sinai Health System, Los Angeles, California, USA.
Mackenzie BearDepartment of Pharmacy Services, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Olga RosenDepartment of Pharmacy Services, Cedars-Sinai Medical Center, Los Angeles, California, USA.
David SekiDepartment of Pharmacy Services, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Brian DoyleGeneral Internal Medicine and Health Services Research, UCLA, Los Angeles, California, USA.
Anish DesaiDepartment of Medicine, Division of General Internal Medicine, Cedars-Sinai Health System, Los Angeles, California, USA.
Douglas S BellGeneral Internal Medicine and Health Services Research, UCLA, Los Angeles, California, USA.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Clinical and Translational Science InstituteKL2TR000122 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$4.5M
Minimizing Errors in Medication Histories Obtained at Hospital AdmissionK23AG049181 · NIA · CEDARS-SINAI MEDICAL CENTER · PI PEVNICK, JOSHUA M · 2015 to 2018
$707k
NCATS NIH HHS KL2 TR000122NCATS NIH HHS UL1 TR000124NIA NIH HHS K23 AG049181NIA NIH HHS L30 AG048588
6 · The paper itself

Abstract

backgroundAdmission medication history (AMH) errors frequently cause medication order errors and patient harm.

objectiveTo quantify AMH error reduction achieved when pharmacy staff obtain AMHs before admission medication orders (AMO) are placed.

methodsThis was a three-arm randomised controlled trial of 306 inpatients. In one intervention arm, pharmacists, and in the second intervention arm, pharmacy technicians, obtained initial AMHs prior to admission. They obtained and reconciled medication information from multiple sources. All arms, including the control arm, received usual AMH care, which included variation in several common processes. The primary outcome was severity-weighted mean AMH error score. To detect AMH errors, all patients received reference standard AMHs, which were compared with intervention and control group AMHs. AMH errors and resultant AMO errors were independently identified and rated by ≥2 investigators as significant, serious or life threatening. Each error was assigned 1, 4 or 9 points, respectively, to calculate severity-weighted AMH and AMO error scores for each patient.

resultsPatient characteristics were similar across arms (mean±SD age 72±16 years, number of medications 15±7). Analysis was limited to 278 patients (91%) with reference standard AMHs. Mean±SD AMH errors per patient in the usual care, pharmacist and technician arms were 8.0±5.6, 1.4±1.9 and 1.5±2.1, respectively (p<0.0001). Mean±SD severity-weighted AMH error scores were 23.0±16.1, 4.1±6.8 and 4.1±7.0 per patient, respectively (p<0.0001). These AMH errors led to a mean±SD of 3.2±2.9, 0.6±1.1 and 0.6±1.1 AMO errors per patient, and mean severity-weighted AMO error scores of 6.9±7.2, 1.5±2.9 and 1.2±2.5 per patient, respectively (both p<0.0001).

conclusionsPharmacists and technicians reduced AMH errors and resultant AMO errors by over 80%. Future research should examine other sites and patient-centred outcomes. TRIAL REGISTRATION NUMBER: NCT02026453.

Indexed as

Professional-Patient RelationsAcademic Medical CentersAgedAged, 80 and overAnalysis of VarianceEmergency Service, HospitalFemaleHumansInterviews as TopicLos AngelesMaleMedication ErrorsMedication ReconciliationMiddle AgedPharmacistsPharmacy Technicianshealthcare quality improvementhealth services researchhuman errormedication reconciliationpharmacists

Identifiers

PMID28986515
PMCPMC5912995

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.