Evidence map›Paper›PMID 28986453›Full record

ArticleCirculation. Cardiovascular genetics2017

Reduced Cardiac

Rachel Zarndt, Stanley M Walls, Karen Ocorr, Rolf Bodmer

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rachel ZarndtFrom the Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute (R.Z., S.M.W., K.O., R.B.) and Biomedical Sciences Graduate Program, School of Medicine, University of California at San Diego (R.Z.), La Jolla, CA.
Stanley M WallsFrom the Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute (R.Z., S.M.W., K.O., R.B.) and Biomedical Sciences Graduate Program, School of Medicine, University of California at San Diego (R.Z.), La Jolla, CA.
Karen OcorrFrom the Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute (R.Z., S.M.W., K.O., R.B.) and Biomedical Sciences Graduate Program, School of Medicine, University of California at San Diego (R.Z.), La Jolla, CA. rolf@sbpdiscovery.org kocorr@sbpdiscovery.org.
Rolf BodmerFrom the Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute (R.Z., S.M.W., K.O., R.B.) and Biomedical Sciences Graduate Program, School of Medicine, University of California at San Diego (R.Z.), La Jolla, CA. rolf@sbpdiscovery.org kocorr@sbpdiscovery.org.
Discovery Institute · US

Funding

HEART DEVELOPMENT IN DROSOPHILAR01HL054732 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BODMER, ROLF · 1995 to 2024
$11.3M
Systems Biology CoreP01HL098053 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POWELL, FRANK L. · 2010 to 2014
$10.2M
GENETIC ANALYSIS OF SLEEP SENECENCEP01AG033561 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BODMER, ROLF · 2011 to 2015
$6.3M
Cellular/molecular substrates linking channel dysfunction and pathological cardiac remodelingR01HL132241 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI OCORR, KAREN · 2017 to 2020
$1.9M
2009 Insulin-like Growth Factors in Physiology and Disease Gordon Research ConferR13AG033456 · NIA · GORDON RESEARCH CONFERENCES · PI ROTWEIN, PETER S · 2009 to 2013
$43k
NHLBI NIH HHS P01 HL098053NHLBI NIH HHS R01 HL054732NHLBI NIH HHS R01 HL132241NIA NIH HHS P01 AG033561NIA NIH HHS R13 AG033456
6 · The paper itself

Abstract

backgroundHypoxia is often associated with cardiopulmonary diseases, which represent some of the leading causes of mortality worldwide. Long-term hypoxia exposures, whether from disease or environmental condition, can cause cardiomyopathy and lead to heart failure. Indeed, hypoxia-induced heart failure is a hallmark feature of chronic mountain sickness in maladapted populations living at high altitude. In a previously established METHODS AND

resultsIn the present study, we explore the function of

conclusionsOur results suggest a key role for calcineurin in cardiac remodeling during long-term hypoxia with implications for diseases of chronic hypoxia, and it likely contributes to mechanisms underlying these disease states.

Indexed as

Down-RegulationGene Expression Regulation, EnzymologicMutation, MissenseAmino Acid SubstitutionAnimalsCalcineurinDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsHeart Defects, CongenitalHypoxiaMyocardiumCalcineurinDrosophila ProteinsCanAcardiac remodelingcardiomyopathychronic ischemic heart diseasechronic mountain sicknesshypertrophyhypoxia adaptation

Identifiers

PMID28986453
PMCPMC5669044
OpenAlexW2760842651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.