Evidence map›Paper›PMID 28986438›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.

Richard M Powell, David Lissauer, Jennifer Tamblyn, Andrew Beggs, Philip Cox, Paul Moss, Mark D Kilby

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo-Antigens.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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  13. Regulatory KIRScience translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Richard M PowellInstitute of Immunology and Immunotherapy, Birmingham Health Partners, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom; richardpowell1000@googlemail.com.
David LissauerCentre for Women's and Newborn Health, Birmingham Health Partners, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0002-7878-2327
Jennifer TamblynCentre for Women's and Newborn Health, Birmingham Health Partners, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0001-6551-3323
Andrew BeggsInstitute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom; and.ORCID 0000-0003-0784-2967
Philip CoxDepartment of Perinatal Pathology, Centre of Women's and Children's Health, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Paul MossInstitute of Immunology and Immunotherapy, Birmingham Health Partners, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0002-6895-1967
Mark D KilbyCentre for Women's and Newborn Health, Birmingham Health Partners, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
University of Birmingham · GB

Funding

Medical Research Council MR/M009157/1Wellcome Trust
6 · The paper itself

Abstract

Immune tolerance during human pregnancy is maintained by a range of modifications to the local and systemic maternal immune system. Lymphoid infiltration is seen at the implantation site of the fetal-maternal interface, and decidual NK cells have been demonstrated to facilitate extravillous trophoblast invasion into maternal decidua during the first trimester, optimizing hemochorial placentation. However, although there is considerable T cell infiltration of the maternal decidua, the functional properties of this T cell response remain poorly defined. We investigated the specificity and regulation of CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedDeciduaFemaleFetusHumansImmune ToleranceImmunologic MemoryImmunophenotypingInterferon-gammaInterleukin-4PregnancyResponse ElementsSignal TransductionInterferon-gammaInterleukin-4

Identifiers

PMID28986438
PMCPMC5679367
OpenAlexW2761988651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.