ArticleJournal of lipid research2017
Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.
Abstract read
In one paragraph
Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
209 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical lipidomics in bacterial sepsis: a systematic review of serum and plasma evaluations.Metabolomics : Official journal of the Metabolomic Society · 2026Pooled it
- Milk polar lipids favorably alter circulating and intestinal ceramide and sphingomyelin species in postmenopausal women.JCI insight · 2021Trial
- Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial.Endocrinology, diabetes & metabolism · 2021Trial
- Trial
- Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.Scientific reports · 2018Trial
- A targeted lipidomics workflow for high-throughput phenotyping and mechanism-based in vitro hepatotoxicity studies.Toxicology in vitro : an international journal published in association with BIBRA · 2026Article
- Standard Reference Material (SRM®) 1950 metabolites in frozen human plasma-use, impact, lessons learned, and future perspectives.Analytical and bioanalytical chemistry · 2026Review
- Population-Associated Molecular Variation in Histologically Normal Breast Tissue Is Associated with Distinct Baseline Transcriptional States.International journal of molecular sciences · 2026Article
- A fast method to quantify free and esterified cholesterol in human plasma and disease models.Journal of lipid research · 2026Article
- Redefining reference materials for the evolving metabolomics landscape.Analytical and bioanalytical chemistry · 2026Review
- Lipid Metabolic Reprogramming and Bioactive Lipid Signaling in MASLD: Molecular Mechanisms, Pathogenesis and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Sphingolipid Metabolism in Obesity: Bidirectional Regulation and Comparative Perspectives on Plant Sphingolipids.Nutrients · 2026Review
- Method-Dependent Variability in Hempseed Lipidomics: Combined Influence of Extraction, Derivatisation, and Genotype on Fatty Acid Composition and Stability.Molecules (Basel, Switzerland) · 2026Article
- Diet-Induced Ceramide Remodeling as a Mechanistic Link to Cardiac Metabolic Dysfunction.Nutrients · 2026Review
- LipiDetective: a deep learning model for the identification of molecular lipid species in tandem mass spectra.Briefings in bioinformatics · 2026Article
- The Language of Elution: Autoregressive Prediction of the Next Feature in Untargeted LC-HRMS Lipidomics.ArXiv · 2026Article
- A lipidomics roadmap: from basic research to societal challenges.Nature communications · 2026Review
- Lipidomics Reveals Circulating Lipid Biomarkers for Retinopathy of Prematurity in Preterm Infants.Ophthalmology science · 2026Article
- Altered Lipid and Neurotransmitter Metabolism as Potential Mechanisms of Weight Gain in Women With HIV Initiating INSTIs in a Pilot Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Biomarkers in Disease Diagnosis and Monitoring: Insights into Clinical Applications and Mass Spectrometry-based Detection.Applied biochemistry and biotechnology · 2026Review
149 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
94 authors.
John A BowdenMarine Biochemical Sciences Group, Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC john.bowden@nist.gov.
Alan HeckertStatistical Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD.
Candice Z UlmerMarine Biochemical Sciences Group, Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC.
Christina M JonesMarine Biochemical Sciences Group, Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC.
Jeremy P KoelmelDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL.
Laila AbdullahThe Roskamp Institute, Sarasota, FL.
Linda AhonenSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Yazen AlnoutiDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE.
Aaron M ArmandoDepartments of Chemistry and Biochemistry and Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA.
Takeshi BambaDivision of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan.
John R BarrDivision of Laboratory Sciences, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA.
Jonas BergquistDepartment of Chemistry-BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden.
Christoph H BorchersUniversity of Victoria-Genome British Columbia Proteomics Centre, University of Victoria, Victoria, British Columbia, Canada.
Joost BrandsmaFaculty of Medicine, Academic Unit of Clinical and Experimental Sciences, Southampton General Hospital, University of Southampton, Southampton, United Kingdom.
Susanne B BreitkopfDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA.
Tomas CajkaNational Institutes of Health West Coast Metabolomics Center, University of California Davis Genome Center, Davis, CA.
Amaury Cazenave-GassiotDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore and Singapore Lipidomic Incubator (SLING), Life Sciences Institute, Singapore.
Antonio ChecaDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Michelle A CinelBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Romain A ColasDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Serge CremersBiomarker Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY.
Edward A DennisDepartments of Chemistry and Biochemistry and Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA.
James E EvansThe Roskamp Institute, Sarasota, FL.
Alexander FaulandDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Oliver FiehnNational Institutes of Health West Coast Metabolomics Center, University of California Davis Genome Center, Davis, CA.
Michael S GardnerDivision of Laboratory Sciences, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA.
Timothy J GarrettDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL.
Katherine H GotlingerDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, NY.
Jun HanUniversity of Victoria-Genome British Columbia Proteomics Centre, University of Victoria, Victoria, British Columbia, Canada.
Yingying HuangThermo Fisher Scientific, San Jose, CA.
Aveline Huipeng NeoDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore and Singapore Lipidomic Incubator (SLING), Life Sciences Institute, Singapore.
Tuulia HyötyläinenDepartment of Chemistry, Örebro University, Örebro, Sweden.
Yoshihiro IzumiDivision of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan.
Hongfeng JiangBiomarker Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY.
Houli JiangDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, NY.
Jiang JiangDepartments of Chemistry and Biochemistry and Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA.
Maureen KachmanMetabolomics Core, BRCF, University of Michigan, Ann Arbor, MI.
Reiko KiyonamiThermo Fisher Scientific, San Jose, CA.
Kristaps KlavinsBiocrates Life Sciences AG, Innsbruck, Austria.
Christian KloseLipotype GmbH, Dresden, Germany.
Harald C KöfelerCore Facility for Mass Spectrometry, Medical University of Graz, Graz, Austria.
Johan KolmertDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Therese KoalBiocrates Life Sciences AG, Innsbruck, Austria.
Grielof KosterFaculty of Medicine, Academic Unit of Clinical and Experimental Sciences, Southampton General Hospital, University of Southampton, Southampton, United Kingdom.
Zsuzsanna KuklenyikDivision of Laboratory Sciences, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA.
Irwin J KurlandStable Isotope and Metabolomics Core Facility, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY.
Michael LeadleyAnalytical Facility of Bioactive Molecules, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Karen LinUniversity of Victoria-Genome British Columbia Proteomics Centre, University of Victoria, Victoria, British Columbia, Canada.
Krishna Rao MaddipatiLipidomics Core Facility and Department of Pathology, Wayne State University, Detroit, MI.
Danielle McDougallDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL.
Peter J MeikleBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Natalie A MellettBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Cian MonninDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada.
M Arthur MoseleyProteomics and Metabolomics Shared Resource, Levine Science Research Center, Duke University School of Medicine, Durham, NC.
Renu NandakumarBiomarker Core Laboratory, Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY.
Matej OresicTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Rainey PattersonDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL.
David PeakeThermo Fisher Scientific, San Jose, CA.
Jason S PierceDepartment of Biochemistry and Molecular Biology Medical University of South Carolina, Charleston, SC.
Martin PostAnalytical Facility of Bioactive Molecules, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Anthony D PostleFaculty of Medicine, Academic Unit of Clinical and Experimental Sciences, Southampton General Hospital, University of Southampton, Southampton, United Kingdom.
Rebecca PughChemical Sciences Division, Environmental Specimen Bank Group, Hollings Marine Laboratory, National Institute of Standards and Technology, Charleston, SC.
Yunping QiuStable Isotope and Metabolomics Core Facility, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY.
Oswald QuehenbergerDepartments of Medicine and Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA.
Parsram RamrupDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada.
Jon ReesDivision of Laboratory Sciences, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA.
Barbara RembiesaDepartment of Biochemistry and Molecular Biology Medical University of South Carolina, Charleston, SC.
Denis ReynaudAnalytical Facility of Bioactive Molecules, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Mary R RothDivision of Biology, Kansas Lipidomics Research Center, Kansas State University, Manhattan, KS.
Susanne SalesMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Kai SchuhmannMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Michal Laniado SchwartzmanDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, NY.
Charles N SerhanDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Andrej ShevchenkoMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Stephen E SomervilleHollings Marine Laboratory, Medical University of South Carolina, Charleston, SC.
Lisa St John-WilliamsProteomics and Metabolomics Shared Resource, Levine Science Research Center, Duke University School of Medicine, Durham, NC.
Michal A SurmaLipotype GmbH, Dresden, Germany.
Hiroaki TakedaDivision of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan.
Rhishikesh ThakareDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE.
J Will ThompsonProteomics and Metabolomics Shared Resource, Levine Science Research Center, Duke University School of Medicine, Durham, NC.
Federico TortaDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore and Singapore Lipidomic Incubator (SLING), Life Sciences Institute, Singapore.
Alexander TrieblCore Facility for Mass Spectrometry, Medical University of Graz, Graz, Austria.
Martin TrötzmüllerCore Facility for Mass Spectrometry, Medical University of Graz, Graz, Austria.
S J Kumari UbhayasekeraDepartment of Chemistry-BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden.
Dajana VuckovicDepartment of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada.
Jacquelyn M WeirBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Ruth WeltiDivision of Biology, Kansas Lipidomics Research Center, Kansas State University, Manhattan, KS.
Markus R WenkDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore and Singapore Lipidomic Incubator (SLING), Life Sciences Institute, Singapore.
Craig E WheelockDivision of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Libin YaoDivision of Biology, Kansas Lipidomics Research Center, Kansas State University, Manhattan, KS.
Min YuanDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA.
Xueqing Heather ZhaoStable Isotope and Metabolomics Core Facility, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY.
Senlin ZhouLipidomics Core Facility and Department of Pathology, Wayne State University, Detroit, MI.
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6MClinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MSTEROL LIPIDSU54GM069338 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 2003 to 2013
$72.2MUNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2001 to 2011
$38.1MUsing social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MVasoregulatory Function of CYP2E1-Derived EicosanoidsP01HL034300 · NHLBI · NEW YORK MEDICAL COLLEGE · PI SCHWARTZMAN, MICHAL LANIADO · 1985 to 2015
$33.4MStable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MResolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PETASIS, NICOS A · 2011 to 2020
$14.8MWest Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001873NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA006516NCRR NIH HHS P20 RR016475NCRR NIH HHS S10 RR027926NHLBI NIH HHS P01 HL034300NHLBI NIH HHS P20 HL113452NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK064391NIDDK NIH HHS U24 DK097154NIDDK NIH HHS U24 DK097209NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R01 GM020501NIGMS NIH HHS U54 GM069338
Abstract
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950-Metabolites in Frozen Human Plasma, a commercially available reference material. The interlaboratory study comprised 31 diverse laboratories, with each laboratory using a different lipidomics workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates and associated uncertainties were determined for 339 of these lipids measured at the sum composition level by five or more participating laboratories. These evaluated lipids detected in SRM 1950 serve as community-wide benchmarks for intra- and interlaboratory quality control and method validation. These analyses were performed using nonstandardized laboratory-independent workflows. The consensus locations were also compared with a previous examination of SRM 1950 by the LIPID MAPS consortium. While the central theme of the interlaboratory study was to provide values to help harmonize lipids, lipid mediators, and precursor measurements across the community, it was also initiated to stimulate a discussion regarding areas in need of improvement.
Indexed as
BenchmarkingHumansInternational CooperationLaboratory Proficiency TestingLipid MetabolismLipidsObserver VariationReference StandardsReproducibility of ResultsLipidsfatty acylsglycerolipidslipidsNational Institute of Standards and Technologyphospholipidsquality controlquantitationsphingolipidsStandard Reference Material 1950sterols
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.