Evidence map›Paper›PMID 28986357›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation.

Vasundhara Kain, Kevin A Ingle, Maureen Kachman, Heidi Baum, Gobinath Shanmugam, Namakkal S Rajasekaran, Martin E Young, Ganesh V Halade

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 59 citations in OpenAlex.

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  14. Extrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure.American journal of physiology. Heart and circulatory physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vasundhara KainDivision of Cardiovascular Disease, Department of Medicine , Birmingham, Alabama.
Kevin A IngleDivision of Cardiovascular Disease, Department of Medicine , Birmingham, Alabama.
Maureen KachmanDepartment of Internal Medicine, University of Michigan , Ann Arbor, Michigan.
Heidi BaumDepartment of Internal Medicine, University of Michigan , Ann Arbor, Michigan.
Gobinath ShanmugamDepartment of Pathology, University of Alabama at Birmingham , Birmingham, Alabama.
Namakkal S RajasekaranDepartment of Pathology, University of Alabama at Birmingham , Birmingham, Alabama.
Martin E YoungDivision of Cardiovascular Disease, Department of Medicine , Birmingham, Alabama.
Ganesh V HaladeDivision of Cardiovascular Disease, Department of Medicine , Birmingham, Alabama.
University of Alabama at Birmingham · USUniversity of Michigan–Ann Arbor · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Reductive Stress Induces Proteotoxic Cardiac DiseaseR01HL118067 · NHLBI · UNIVERSITY OF UTAH · PI NAMAKKAL SOORAPPAN, RAJASEKARAN · 2013 to 2021
$4.5M
Resolution of Inflammation in Heart Failure Post-Myocardial InfarctionR01HL132989 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2016 to 2020
$1.8M
NHLBI NIH HHS R01 HL118067NHLBI NIH HHS R01 HL132989NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Maintaining a balance of ω-6 and ω-3 fatty acids is essential for cardiac health. Current ω-6 and ω-3 fatty acids in the American diet have shifted from the ideal ratio of 2:1 to almost 20:1; while there is a body of evidence that suggests the negative impact of such a shift in younger organisms, the underlying age-related metabolic signaling in response to the excess influx of ω-6 fatty acids is incompletely understood. In the present study, young (6 mo old) and aging (≥18 mo old) mice were fed for 2 mo with a ω-6-enriched diet. Excess intake of ω-6 enrichment decreased the total lean mass and increased nighttime carbohydrate utilization, with higher levels of cardiac cytokines indicating low-grade chronic inflammation. Dobutamine-induced stress tests displayed an increase in PR interval, a sign of an atrioventricular defect in ω-6-fed aging mice. Excess ω-6 fatty acid intake in aging mice showed decreased 12-lipoxygenase with a concomitant increase in 15-lipoxygenase levels, resulting in the generation of 15( S)-hydroxyeicosatetraenoic acid, whereas cyclooxygenase-1 and -2 generated prostaglandin E

Indexed as

Animal Nutritional Physiological PhenomenaElectrocardiographyAction PotentialsAge FactorsAgingAnimal FeedAnimalsArrhythmias, CardiacChronic DiseaseCytokinesEnergy MetabolismFatty Acids, Omega-6Heart Conduction SystemHeart RateInflammationInflammation MediatorsCytokinesFatty Acids, Omega-6Inflammation Mediatorsagingfatty acidsinflammationlipid signalingmetabolism

Identifiers

PMID28986357
PMCPMC5867649
OpenAlexW2761192460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.