Evidence map›Paper›PMID 28986247›Full record

ArticleActa tropica2018

The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic.

Yamilka Díaz, Julio Cisneros, Hilda Guzmán, Paola Cordoba, Jean-Paul Carrera, Brechla Moreno, Rubing Chen, Juan Castillo Mewa, Lourdes García, Lizbeth Cerezo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta tropica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Yamilka DíazDepartment of Research in Virology and Biotechnology Department, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35st Street, 0816-02593, Panama.
Julio CisnerosDepartment of Research in Virology and Biotechnology Department, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35st Street, 0816-02593, Panama.
Hilda GuzmánDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States.
Paola CordobaDepartment of Research in Virology and Biotechnology Department, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35st Street, 0816-02593, Panama.
Jean-Paul CarreraDepartment of Research in Virology and Biotechnology Department, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35st Street, 0816-02593, Panama.
Brechla MorenoDepartment of Research in Virology and Biotechnology Department, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35st Street, 0816-02593, Panama.
Rubing ChenDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States.
Juan Castillo MewaDepartment of Research in Genetics and Proteomics, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35 St Street, 0816-02593, Panama.
Lourdes GarcíaEpidemiology Department, Ministry of Health of Panama, Panama City, Ancon, Gorgas street, building 265, Panama.
Lizbeth CerezoEpidemiology Department, Ministry of Health of Panama, Panama City, Ancon, Gorgas street, building 265, Panama.
Amelia Travassos da RosaDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States.
Nathan D GundackerUniversity of Alabama at Birmingham, Birmingham, Alabama, Birminghan AL 35294, United States.
Blas ArmiénDepartment of Research in Zoonotic and emergent diseases, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena avenue and 35St street, 0816-02593, Panama; Research Direction, Universidad Interamericana de Panama, Panama City, Ricardo J. Alfaro Avenue, Panama.
Scott C WeaverDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States; Center for Tropical Diseases and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States.
Nikos VasilakisDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States; Center for Tropical Diseases and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States.
Sandra López-VergèsDepartment of Research in Virology and Biotechnology Department, Gorgas Memorial Institute of Health Studies, Panama City, Justo Arosemena Avenue and 35st Street, 0816-02593, Panama. Electronic address: slopez@gorgas.gob.pa.
Robert TeshDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States. Electronic address: rbtesh@comcast.net.
Instituto Conmemorativo Gorgas de Estudios de la Salud · PAThe University of Texas Medical Branch at Galveston · USUniversity of Alabama at Birmingham · US

Funding

World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
NIAID NIH HHS HHSN272201000040INIAID NIH HHS R24 AI120942
6 · The paper itself

Abstract

The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and -3 were predominant. Herein, we describe the 2011 Panama outbreak and genetically characterize the Panamanian DENV-2 strains, which were associated with severe dengue disease in Panama. Our results suggest that the DENV-2 isolates from this outbreak belonged to the AS/AM genotype sub-clade 2BI and were genetically close to viruses described in the outbreaks in Nicaragua, Honduras, Guatemala and Mexico from 2006-2011. Sub-clade 2BI has previously been associated with severe disease in Nicaragua during outbreaks from 2005-2007.

Indexed as

AdolescentAdultChildChild, PreschoolDengueDengue VirusDisease OutbreaksFemaleGenotypeHumansInfantMaleMiddle AgedPanamaPhylogenySevere Dengueand case fatality rateDENV-2epidemiologyoutbreakphylogenetics

Identifiers

PMID28986247
PMCPMC6295316
OpenAlexW2764161733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.