ArticleBrain, behavior, and immunity2018
Inflammatory response to mental stress and mental stress induced myocardial ischemia.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis on the prevalence, associated factors and diagnostic methods of mental stress induced myocardial ischemia.Journal of translational medicine · 2020Pooled it
- Neighborhood poverty and hemodynamic, neuroendocrine, and immune response to acute stress among patients with coronary artery disease.Psychoneuroendocrinology · 2019Trial
- Dose-dependent association between elevated resting IL-6 levels and severity of mental stress-induced myocardial perfusion defects.Psychological medicine · 2026Article
- Integrating mental health and cardiovascular wellness: synergistic impacts and the promise of comprehensive care models.Annals of medicine and surgery (2012) · 2025Review
- Psychosocial stress and cardiovascular disease.American journal of preventive cardiology · 2025Review
- Ginsenoside Rb2 Inhibits the Pyroptosis in Myocardial Ischemia Progression Through Regulating the SIRT1 Mediated Deacetylation of ASC.Biochemical genetics · 2025Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Effects of lifestyle factors on leukocytes in cardiovascular health and disease.Nature reviews. Cardiology · 2024Review
- Association Between Symptoms of Chronic Psychological Distress and Myocardial Ischemia Induced by Mental Stress in Patients With Coronary Artery Disease.Journal of the American Heart Association · 2023Article
- "Just the Facts Ma'am": Moral and Ethical Considerations for Artificial Intelligence in Medicine and its Potential to Impact Patient Autonomy and Hope.The Linacre quarterly · 2023Article
- The Impact of Mental Stress on Cardiovascular Health-Part II.Journal of clinical medicine · 2022Review
- Cardiovascular pathophysiology from the cardioneural perspective and its clinical applications.Trends in cardiovascular medicine · 2022Review
- Perceived stress in Chinese patients with coronary heart disease: a cross-sectional study.BMJ open · 2022Article
- Elevated Admission Cardiac Troponin I Predicts Adverse Outcomes of Acute Type B Aortic Dissection after Endovascular Treatment.Frontiers in surgery · 2022Article
- Article
- [Mechanism of PI3K/AKT/mTOR signaling pathway for mediating anti-inflammatory and anti-oxidant effects of chrysin: a protein microarray-based study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Glucocorticoid Inhibition of Estrogen Regulation of the Serotonin Receptor 2B in Cardiomyocytes Exacerbates Cell Death in Hypoxia/Reoxygenation Injury.Journal of the American Heart Association · 2021Article
- Brain-heart connections in stress and cardiovascular disease: Implications for the cardiac patient.Atherosclerosis · 2021Review
- Cross-Sectional Study of the Effects of Job Burnout on Immune Function in 105 Female Oncology Nurses at a Tertiary Oncology Hospital.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The effect of acute exercise on interleukin-6 and hypothalamic-pituitary-adrenal axis responses in patients with coronary artery disease.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
28 authors.
Funding
Abstract
backgroundMental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia.
methodsPatients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor. MSIMI was determined as impaired myocardial perfusion using a 17-segment model. Inflammatory markers including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), matrix metallopeptidase 9 (MMP-9) and high-sensitivity C reactive protein (hsCRP) were measured at rest and 90 min after mental stress. Results were validated in an independent sample of 228 post-myocardial infarction patients.
resultsOf 607 patients analyzed in this study, (mean age 63 ± 9 years, 76% male), 99 (16.3%) developed MSIMI. Mental stress resulted in a significant increase in IL-6, MCP-1, and MMP-9 (all p <0.0001), but not hsCRP. However, the changes in these markers were similar in those with and without MSIMI. Neither resting levels of these biomarkers, nor their changes with mental stress were significantly associated with MSIMI. Results in the replication sample were similar.
conclusionMental stress is associated with acute increases in several inflammatory markers. However, neither the baseline inflammatory status nor the magnitude of the inflammatory response to mental stress over 90 min were significantly associated with MSIMI.
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