Evidence map›Paper›PMID 28986209›Full record

ArticleNeurotoxicology and teratology2017

Effects of prenatal alcohol exposure in a prospective sample of young adults: Mental health, substance use, and difficulties with the legal system.

Mary Ellen Lynch, Julie A Kable, Claire D Coles

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology and teratology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Prenatal Alcohol Exposure and Dysmorphic Features in Adults at Midlife.Alcohol, clinical & experimental research · 2026
    Article
  5. Review
  6. Fetal Alcohol Spectrum Disorders.Current topics in behavioral neurosciences · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Alterations in Insulin Levels in Adults with Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2021
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mary Ellen LynchCenter for Maternal Substance Abuse and Child Development, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive NE, Suite 200, Atlanta, GA 30329, United States.. Electronic address: mlynch@emory.edu.
Julie A KableCenter for Maternal Substance Abuse and Child Development, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive NE, Suite 200, Atlanta, GA 30329, United States.. Electronic address: jkabl01@emory.edu.
Claire D ColesCenter for Maternal Substance Abuse and Child Development, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive NE, Suite 200, Atlanta, GA 30329, United States.. Electronic address: ccoles@emory.edu.
Emory University · US

Funding

Prenatal Alcohol Exposure: Adult NeurocognitionR01AA014373 · NIAAA · EMORY UNIVERSITY · PI COLES, CLAIRE D · 2003 to 2007
$2.8M
NIAAA NIH HHS R01 AA014373
6 · The paper itself

Abstract

introductionFew studies have focused on the transition to adulthood in adults with prenatal alcohol exposure (PAE). In this study, we examine the occurrence of problem behavior at this transition, including mental health problems, substance use, and difficulties with the legal system. The sample is prospective and provides an opportunity to examine effects of a wide range of prenatal exposure. Adults with PAE were expected to show more problem behavior; the impact of level of exposure was examined as well.

methodThe sample was drawn from a predominantly low-income, African-American population. Mothers of the alcohol-exposed participants (n=123) and those in the non-exposed SES-Control group (CONT) (n=59) were recruited at a prenatal visit when information on alcohol and drug use during pregnancy was collected. A disability contrast group (n=54) was recruited at adolescence. The adults with PAE were assigned to three groups varying in physical and cognitive effects of exposure. This report is based on the adults' responses to interviews or questionnaires on problem behavior and laboratory tests related to substance use.

resultsAdults with PAE showed more problem behavior in all three areas than adults from the CONT group. For mental health problems, the exposed group showing cognitive, but not physical effects, had the highest scores; their scores were similar, however, to those of the disability contrast group on several scales. Results for outcomes on substance use and legal difficulties were less consistent, but, when significant effects occurred, the group that was exposed, but neither physically nor cognitively affected, was more likely to show negative outcomes. Males in this group were most involved in these behaviors.

conclusionEffects of PAE continue into early adulthood and affect mental health problems, substance use, and interactions with the legal system. Adults who are exposed, but less physically affected, seem to be the most involved in problem behavior. More research is necessary to examine environmental effects in conjunction with PAE on these outcomes and to provide a basis for developing potential interventions.

Indexed as

Problem BehaviorBlack or African AmericanCriminalsEthanolFemaleHumansMaleMaternal ExposureMental HealthPovertyPregnancyPrenatal Exposure Delayed EffectsProspective StudiesSubstance-Related DisordersEthanolLegal difficultiesMental healthPrenatal alcohol exposureSubstance useTransition to adulthood

Identifiers

PMID28986209
PMCPMC5739524
OpenAlexW2763987401

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.