ArticleJournal of hematology & oncology2017
An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia.
Article in Journal of hematology & oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development of humanized mouse with patient-derived xenografts for cancer immunotherapy studies: A comprehensive review.Cancer science · 2021Pooled it
- Advancing precision therapy in pediatric acute myeloid leukemia through PDX models and mitochondrial targeting.Blood advances · 2026Article
- Advances in the application of patient-derived xenograft models in acute leukemia resistance.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Establishment of human acute monocytic leukemia model with systemic infiltration in NPG mice.Histology and histopathology · 2024Article
- Article
- Human Serum Albumin Based Nanodrug Delivery Systems: Recent Advances and Future Perspective.Polymers · 2023Review
- CD34Frontiers in cell and developmental biology · 2023Article
- Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia.Journal of nanobiotechnology · 2022Article
- Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China.Acta pharmaceutica Sinica. B · 2021Article
- Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents.Signal transduction and targeted therapy · 2021Review
- Reference Values for Hematology, Plasma Biochemistry, Bone Marrow Cytology and Bone Histology of NODJournal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Differential Localization and Invasion of Tumor Cells in Mouse Models of Human and Murine Leukemias.Acta histochemica et cytochemica · 2020Article
- LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- [Advances in the mouse models of myeloid leukemia].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Review
- Pilot Study of an Integrative New Tool for Studying Clinical Outcome Discrimination in Acute Leukemia.Frontiers in oncology · 2019Article
- Humanized Mice as Unique Tools for Human-Specific Studies.Archivum immunologiae et therapiae experimentalis · 2018Review
- Heterogeneous expression of EPCAM in human circulating tumour cells from patient-derived xenografts.Biomarker research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXenotransplantation of patient-derived AML (acute myeloid leukemia) cells in NOD-scid Il2rγ
methodsHere, we describe an improved AML xenograft model where primary human AML cells were injected into NSG newborn pups intrahepatically.
resultsIntroduction of primary cells from AML patients resulted in high levels of engraftment in peripheral blood, spleen, and bone marrow (BM) of recipient mice. The phenotype of engrafted AML cells remained unaltered during serial transplantation. The mice developed features that are consistent with human AML including spleen enlargement and infiltration of AML cells into multiple organs. Importantly, we demonstrated that although leukemic stem cell activity is enriched and mediated by CD34
conclusionsCollectively, our improved model is robust, easy-to-construct, and reliable for pre-clinical AML studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.