ArticleHealth and quality of life outcomes2017
Health-related quality of life in children with congenital adrenal hyperplasia.
Article in Health and quality of life outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Glucocorticoid reduction after starting crinecerfont in pediatric patients with classic congenital adrenal hyperplasia: practical perspectives.The Journal of clinical endocrinology and metabolism · 2026Review
- Evaluation of Sleep Health in Children With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.The Journal of clinical endocrinology and metabolism · 2025Article
- Psychosocial Development, Sexuality and Quality of Life in Congenital Adrenal HyperplasiaJournal of clinical research in pediatric endocrinology · 2025Review
- The clinical characteristics and quality of life of 248 pediatric and adult patients with Congenital Adrenal Hyperplasia.Frontiers in endocrinology · 2023Article
- Health status of children and young persons with congenital adrenal hyperplasia in the UK (CAH-UK): a cross-sectional multi-centre study.European journal of endocrinology · 2022Article
- The impact of adherence and therapy regimens on quality of life in patients with congenital adrenal hyperplasia.Clinical endocrinology · 2022Article
- Article
- The way toward adulthood for females with nonclassic congenital adrenal hyperplasia.Endocrine · 2021Review
- Health-related quality of life and fatigue perception in children with congenital adrenal hyperplasia: A Developing nation perspective.Pediatric endocrinology, diabetes, and metabolism · 2021Article
- We All Have a Role to Play: Redressing Inequities for Children Living with CAH and Other Chronic Health Conditions of Childhood in Resource-Poor Settings.International journal of neonatal screening · 2020Article
- Manipulation of Hydrocortisone Tablets Leads to Iatrogenic Cushing Syndrome in a 6-Year-Old Girl With CAH.Journal of the Endocrine Society · 2020Article
- Adrenal Insufficiency in Young Children: a Mixed Methods Study of Parents' Experiences.Journal of genetic counseling · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundChildren with congenital adrenal hyperplasia (CAH) require life-long glucocorticoid replacement and have daily intermittent hyper/hypocortisolemia and hyperandrogenemia. Health-related quality of life (HRQL) is important for understanding the impact the disease and therapy have on physical, mental, emotional, and social functioning. Little is known about HRQL in CAH. We compared HRQL in children with CAH to healthy norms and examined how these scores related to physiologic variables.
methodsA cross-sectional study examined 45 patients (mean age 8.2(4.5) years). Thirty-two self-reported their quality of life (QoL) on the PedsQL™ Generic Core Scale and PedsQL™ Fatigue Scale, and 44 parents completed a parent report. Bone age Z-scores were calculated from the most recent bone age.
resultsChildren with CAH did not report lower QoL than healthy norms. However, their parents reported lower overall QoL and fatigue scores than parents of healthy norms. Children with CAH rated sleep poorer than their parents. QoL scores did not differ by sex or CAH subtype and were not associated with total daily hydrocortisone dose. Bone age Z-scores were negatively associated with child-reported emotional health and cognitive fatigue.
conclusionsParents of children with CAH reported a negative impact of disease on their children's QoL, but their children did not. The negative associations between bone age Z-scores and emotional health and cognitive fatigue suggest an impact from chronic hypocortisolemia and hyperandrogenemia.
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