SynthesisBMC medical genetics2017
Gender differences in the prevalence of congenital heart disease in Down's syndrome: a brief meta-analysis.
Synthesis in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Sex differences in cardiovascular disease and dysregulation in Down syndrome.American journal of physiology. Heart and circulatory physiology · 2023Pooled it
- Case report: acute phosphine inhalation poisoning in a patient with Down's syndrome.International journal of emergency medicine · 2026Article
- TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome.Physiological reports · 2025Article
- Prevalence and risk factors analysis of early postoperative arrhythmia after congenital heart surgery in pediatric patients.Journal of arrhythmia · 2024Article
- Congenital Heart Defects and Outcome in a Large Cohort of Down Syndrome: A Single-Center Experience from Turkey.Turkish archives of pediatrics · 2023Article
- [Congenital heart disease in Down's syndrome].Archivos de cardiologia de Mexico · 2023Article
- Sex Differences in Protein Expression and Their Perturbations in Amniotic Fluid Cells of Down Syndrome Fetuses.ACS omega · 2022Article
- Associations of congenital heart disease with deprivation index by rural-urban maternal residence: a population-based retrospective cohort study in Ontario, Canada.BMC pediatrics · 2022Article
- Biochemical Serum Markers Influencing Maternal Age Risk for Down's Syndrome in Quadruple Marker.Cureus · 2022Article
- Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome.Frontiers in neuroscience · 2022Review
- Copy number variation analysis in Chinese children with complete atrioventricular canal and single ventricle.BMC medical genomics · 2021Article
- Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome.American journal of obstetrics and gynecology · 2021Article
- Types and Distribution of Congenital Heart Defects in Pediatric Patients with Down's Syndrome: A Retrospective Study.Cureus · 2020Article
- Lifetime Burden of Adult Congenital Heart Disease in the USA Using a Microsimulation Model.Pediatric cardiology · 2020Article
- Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories.Stem cell reports · 2019Article
- Mature miR-99a Upregulation in the Amniotic Fluid Samples from Female Fetus Down Syndrome Pregnancies: A Pilot Study.Medicina (Kaunas, Lithuania) · 2019Article
- Congenital Cardiovascular Anomalies among Cases of Down Syndrome: A Hospital Based Review of Cases in TikurAnbessa Specialized Hospital, Ethiopia.Ethiopian journal of health sciences · 2019Article
- Gender and its association with cardiac defects in down syndrome population at Children Hospital & Institute of Child Health, Lahore, Pakistan.Pakistan journal of medical sciencesArticle
- Surgical Treatment for Congenital Heart Defects in Down Syndrome Patients.Brazilian journal of cardiovascular surgeryObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDown's syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40-60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.
methodsWe performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.
resultsQuantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.
conclusionCHD, particularly AVSD, are more common in the female gender of Down's syndrome patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.