ArticleCell2017
Lactate Metabolism in Human Lung Tumors.
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Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 850 papers.
0numbers the graph read from it
0cells of the map it votes in
850citing papers in PubMed
36.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
850 citing papers in PubMed, 1,285 citations in OpenAlex.
- Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.Genes & diseases · 2027Review
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Additive hepatotoxicity of seneciphylline and lasiocarpine mixtures: multi-omics insights into P53 driven apoptosis and a Warburg-like metabolic reprogramming.Archives of toxicology · 2026Article
- Lung cancer metabolism: a dynamic and adaptive network.Cellular and molecular life sciences : CMLS · 2026Review
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Lactate Signal: Modulator of Cellular Energy Production and Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Research progress on lactate metabolism in lung cancer: Tumorigenesis, drug resistance and clinical translation (Review).Oncology reports · 2026Review
- Drug sensitivity testing of patient-derived bone sarcomas identifies selective kinase inhibitors for patients with refractory disease.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Spatiotemporal metabolic networks in a preclinical model of pancreatic cancer and associated cachexia.Nature communications · 2026Article
- A simple, anesthesia-free infusion technique for in vivo metabolic tracing.Science advances · 2026Article
- Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response.Current issues in molecular biology · 2026Review
- Single-cell and spatial transcriptomics reveal lactate-active epithelial-immune cell crosstalk that reprograms the immune microenvironment in colorectal cancer.Translational oncology · 2026Article
- Stable Isotope-Resolved Metabolomics in Elucidating Mitochondrial Metabolic Reprogramming and Therapeutic Targets.Biomedical chromatography : BMC · 2026Review
- Lactate Metabolism: Separating Correlation From Causation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Hypoxia-inducible factor-1α promotes the malignant progression of cervical cancer cells by regulating lactate dehydrogenase A-mediated glycolysis.Translational cancer research · 2026Article
- Lactate-induced epithelial-mesenchymal transition: a metabolic nexus in pancreatic cancer metastasis.Translational cancer research · 2026Review
- PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation.Signal transduction and targeted therapy · 2026Review
- Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments.Molecular biomedicine · 2026Review
- Article
- Lactate, Carbohydrate Restriction, and Cancer Metabolism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Review
790 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 4 institutions in 1 country.
Brandon FaubertChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kevin Y LiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ling CaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Christopher T HensleyChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jiyeon KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lauren G ZachariasChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chendong YangChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Quyen N DoDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sarah DoucetteChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Daniel BurgueteDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hong LiClinical Research Unit, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Giselle HuetClinical Research Unit, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Qing YuanDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Trevor WigalDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yasmeen ButtDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Min NiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jose TorrealbaDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dwight OliverDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Robert E LenkinskiDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Craig R MalloyDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jason W WachsmannDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jamey D YoungDepartments of Chemical and Biomolecular Engineering and Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Kemp KernstineDepartment of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: ralph.deberardinis@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USChildren's Medical Center · USSouthwestern Medical Center · USVanderbilt University · US
Funding
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7MUT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5MTR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9MMetabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MIn Vivo 2H/13C Metabolic Flux Analysis of NASH PathogenesisR01DK106348 · NIDDK · VANDERBILT UNIVERSITY · PI YOUNG, JAMEY D. · 2015 to 2019
$1.7MNCATS NIH HHS UL1 TR001105NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA070907NCI NIH HHS R35 CA220449NIBIB NIH HHS P41 EB015908NIDDK NIH HHS R01 DK106348
Abstract
Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle. Here, we show that lactate is also a TCA cycle carbon source for NSCLC. In human NSCLC, evidence of lactate utilization was most apparent in tumors with high
Indexed as
AnimalsBlood Chemical AnalysisCarcinoma, Non-Small-Cell LungCell Line, TumorCitric Acid CycleDisease Models, AnimalFemaleGlyceric AcidsHeterograftsHumansLactic AcidLung NeoplasmsMaleMiceMonocarboxylate Transport Protein 1Monocarboxylic Acid Transporters3-phosphoglycerateGlyceric AcidsLactic AcidMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSymportersCancer metabolismGlycolysisLactateLung cancerMetabolic flux analysisMonocarboxylate transportTricarboxylic Acid CycleWarburg effect
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.