ArticleChemical research in toxicology2017
Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.
Article in Chemical research in toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Can Isoflavone-Rich Legume Plants Be Useful in the Chemoprevention of Hormone-Dependent Cancers?-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Propolis as a potential modulator of aryl hydrocarbon receptor signaling in inflammation.European cytokine network · 2026Review
- Transcriptome analyses of human corneal endothelial cell lines derived from patients with Fuchs endothelial corneal dystrophy.Scientific reports · 2025Article
- Differential Biological Effects ofAntioxidants (Basel, Switzerland) · 2024Article
- Design, synthesis,RSC medicinal chemistry · 2024Article
- DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.).Phytochemistry · 2023Article
- Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer.Bioengineered · 2021Article
- Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor.Molecules (Basel, Switzerland) · 2021Review
- 6-Prenylnaringenin from Hops Disrupts ERα-Mediated Downregulation ofChemical research in toxicology · 2020Article
- KRSC advances · 2020Article
- The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice.Toxicology and applied pharmacology · 2020Article
- Epigenetic Activation ofNutrients · 2019Article
- Potential Anticancer Properties and Mechanisms of Action of Formononetin.BioMed research international · 2019Review
- Evidence for Chemopreventive and Resilience Activity of Licorice:Cancer prevention research (Philadelphia, Pa.) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Many women consider botanical dietary supplements (BDSs) as safe alternatives to hormone therapy for menopausal symptoms. However, the effect of BDSs on breast cancer risk is largely unknown. In the estrogen chemical carcinogenesis pathway, P450 1B1 metabolizes estrogens to 4-hydroxylated catechols, which are oxidized to genotoxic quinones that initiate and promote breast cancer. In contrast, P450 1A1 catalyzed 2-hydroxylation represents a detoxification pathway. The current study evaluated the effects of red clover, a popular BDS used for women's health, and its isoflavones, biochanin A (BA), formononetin (FN), genistein (GN), and daidzein (DZ), on estrogen metabolism. The methoxy estrogen metabolites (2-MeOE
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.