Trial reportSocial cognitive and affective neuroscience2017
Alcohol's effects on emotionally motivated attention, defensive reactivity and subjective anxiety during uncertain threats.
Trial report in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alcohol and Neural Dynamics: A Meta-analysis of Acute Alcohol Effects on Event-Related Brain Potentials.Biological psychiatry · 2021Pooled it
- Using mobile technology to influence alcohol-impaired driving risk perceptions and decisions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Trial
- Sex-Based Mechanisms of Stress-Induced Alcohol-Seeking.Behavioral sciences (Basel, Switzerland) · 2026Article
- Comparison of Post-Consumption Attention Between Two Different Aroma Types of Baijiu Using the Stroop Task.Foods (Basel, Switzerland) · 2025Article
- Alcohol's effects during uncertain and uncontrollable stressors in the laboratory.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats.Journal of neuroscience research · 2021Article
- Posttraumatic stress symptom dimensions and brain responses to startling auditory stimuli in combat veterans.Journal of abnormal psychology · 2021Article
- Stress Allostasis in Substance Use Disorders: Promise, Progress, and Emerging Priorities in Clinical Research.Annual review of clinical psychology · 2020Review
- Heavy marijuana use but not deprivation is associated with increased stressor reactivity.Journal of abnormal psychology · 2018Article
- Increased startle potentiation to unpredictable stressors in alcohol dependence: Possible stress neuroadaptation in humans.Journal of abnormal psychology · 2017Article
- Probing for Neuroadaptations to Unpredictable Stressors in Addiction: Translational Methods and Emerging Evidence.Journal of studies on alcohol and drugs · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Developing a better understanding of how and under what circumstances alcohol affects the emotions, cognitions and neural functions that precede and contribute to dangerous behaviors during intoxication may help to reduce their occurrence. Alcohol intoxication has recently been shown to reduce defensive reactivity and anxiety more during uncertain vs certain threat. However, alcohol's effects on emotionally motivated attention to these threats are unknown. Alcohol may disrupt both affective response to and attentional processing of uncertain threats making intoxicated individuals less able to avoid dangerous and costly behaviors. To test this possibility, we examined the effects of a broad range of blood alcohol concentrations on 96 participants' sub-cortically mediated defensive reactivity (startle potentiation), retrospective subjective anxiety (self-report) and cortically assessed emotionally motivated attention (probe P3 event related potential) while they experienced visually cued uncertain and certain location electric shock threat. As predicted, alcohol decreased defensive reactivity and subjective anxiety more during uncertain vs certain threat. In a novel finding, alcohol dampened emotionally motivated attention during uncertain but not certain threat. This effect appeared independent of alcohol's effects on defensive reactivity and subjective anxiety. These results suggest that alcohol intoxication dampens processing of uncertain threats while leaving processing of certain threats intact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.