ArticlePloS one2017
The pain threshold of high-threshold mechanosensitive receptors subsequent to maximal eccentric exercise is a potential marker in the prediction of DOMS associated impairment.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Information on Placebo in the Informed Consent on the Trial Outcomes and Participant Blinding
Effects of Isometric Exercise on Recovery Following Experimentally Induced Delayed Onset Muscle Soreness: A Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Healthcare providers' pain management practice and its associated factors in Ethiopia: A systematic review and meta- analysis.PloS one · 2024Pooled it
- Sub-maximal endurance exercise does not mediate alterations of somatosensory thresholds.Scientific reports · 2020Trial
- Acute Post-Match Fatigue and Recovery Kinetics of Neuromuscular Performance and Muscle Damage After a Friendly Match in Elite Youth Football Players.Journal of functional morphology and kinesiology · 2026Article
- Recovery kinetics following matches in congested vs. non-congested schedules: effects on pressure pain sensitivity, delayed onset muscle soreness, and muscular performance in soccer players.BMC sports science, medicine & rehabilitation · 2026Article
- Reference Values of Joint-Specific Pressure Pain Thresholds in Healthy Male Individuals: A Retrospective Study.European journal of pain (London, England) · 2025Article
- Pressure-pain thresholds of the plantar foot reflect relative tissue thickness and are systematically higher in active runners than non-runners.Frontiers in physiology · 2025Article
- Exercise induced hypoalgesia after a high intensity functional training: a randomized controlled crossover study.BMC sports science, medicine & rehabilitation · 2024Article
- Pain-Pressure Threshold Changes throughout Repeated Assessments with No Sex Related Differences.Healthcare (Basel, Switzerland) · 2023Article
- Efficacy of a strength-based exercise program in patients with chronic tension type headache: a randomized controlled trial.Frontiers in neurology · 2023Article
- Effects of combined treatment with transcranial and peripheral electromagnetic stimulation on performance and pain recovery from delayed onset muscle soreness induced by eccentric exercise in young athletes. A randomized clinical trial.Frontiers in physiology · 2023Article
- Pain sensitization and atrophy of deep cervical muscles in patients with chronic tension-type headache.Revista da Associacao Medica Brasileira (1992) · 2023Observational
- Deep Cervical Muscles and Functionality in Patients with Chronic Tension-Type Headache: An Observational Study.Medicina (Kaunas, Lithuania) · 2022Observational
- The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study.Global advances in health and medicine · 2022Article
- Incidence of injury and pain in referees in German national handball leagues: a cohort study.BMC sports science, medicine & rehabilitation · 2021Article
- Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT.Frontiers in physiology · 2021Article
- Effects of Acupuncture on Delayed-Onset Muscle Soreness: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging.Frontiers in physiology · 2020Review
- Physical and psychosocial work environmental risk factors of low-back pain: protocol for a 1 year prospective cohort study.BMC musculoskeletal disorders · 2019Article
- Practical Use of the Navigate Pain Application for the Assessment of the Area, Location, and Frequency of the Pain Location in Young Soccer Goalkeepers.Journal of human kinetics · 2019Article
- Acute Effects of Ice Hockey on Hip Range of Motion, Strength, and Pelvic Tilt in Competitive Male Players.Sports healthArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelayed-onset muscle soreness (DOMS) refers to dull pain and discomfort in people after participating in exercise, sport or recreational physical activities. The aim of this study was to detect underlying mechanical thresholds in an experimental model of DOMS.
methodsRandomised study to detect mechanical pain thresholds in a randomised order following experimentally induced DOMS of the non-dominant arm in healthy participants. Main outcome was the detection of the pressure pain threshold (PPT), secondary thresholds included mechanical detection (MDT) and pain thresholds (MPT), pain intensity, pain perceptions and the maximum isometric voluntary force (MIVF).
resultsTwenty volunteers (9 female and 11 male, age 25.2 ± 3.2 years, weight 70.5 ± 10.8 kg, height 177.4 ± 9.4 cm) participated in the study. DOMS reduced the PPT (at baseline 5.9 ± 0.4 kg/cm2) by a maximum of 1.5 ± 1.4 kg/cm2 (-24%) at 48 hours (p < 0.001). This correlated with the decrease in MIVF (r = -0.48, p = 0.033). Whereas subjective pain was an indicator of the early 48 hours, the PPT was still present after 72 hours (r = 0.48, p = 0.036). Other mechanical thresholds altered significantly due to DOMS, but did show no clinically or physiologically remarkable changes.
conclusionsFunctional impairment following DOMS seems related to the increased excitability of high-threshold mechanosensitive nociceptors. The PPT was the most valid mechanical threshold to quantify the extent of dysfunction. Thus PPT rather than pain intensity should be considered a possible marker indicating the athletes' potential risk of injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.