ArticlePloS one2017
Scaling and maintenance of corneal thickness during aging.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Comparative Histology of the Cornea and Palisades of Vogt in Various Non-Human Primates.Veterinary sciences · 2026Article
- Enabling In Vivo Longitudinal Evaluation of Descemet's Membrane Thickness in Wild-type and FECD Mice Using Self-Referenced Optical Coherence Microscopy.Investigative ophthalmology & visual science · 2025Article
- Treatment of nitrogen mustard-induced corneal injury with alpha-melanocyte stimulating hormone.Experimental eye research · 2025Article
- Characteristic visual phenotypes in Korean wild mice (KWM/Hym).Laboratory animal research · 2024Article
- A unique and biocompatible corneal collagen crosslinking in vivo.Scientific reports · 2024Article
- Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard.Experimental eye research · 2023Article
- Investigation of the Effects of Monosodium Glutamate on the Embryonic Development of the Eye in Chickens.Veterinary sciences · 2023Article
- Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications.The ocular surface · 2022Review
- Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs HAmerican journal of physiology. Cell physiology · 2022Article
- Optimal Design of Novel Microemulsions-Based Two-Layered Dissolving Microneedles for Delivering Fluconazole in Treatment of Fungal Eye Infection.Pharmaceutics · 2022Article
- Topical onion juice mitigates the morphological alterations of the cornea in the aged male rats.Anatomy & cell biology · 2021Article
- The ocular surface immune system through the eyes of aging.The ocular surface · 2021Review
- Histopathological changes in tear-secreting tissues and cornea in a mouse model of autoimmune disease.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Article
- The frequency of non-pathologically thin corneas in young healthy adults.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Corneal thickness is tightly regulated by its boundary endothelial and epithelial layers. The regulated set-point of corneal thickness likely shows inter-individual variations, changes by age, and response to stress. Using anterior segment-optical coherence tomography, we measure murine central corneal thickness and report on body size scaling of murine central corneal thickness during aging. For aged-matched mice, we find that corneal thickness depends on sex and strain. To shed mechanistic insights into these anatomical changes, we measure epithelial layer integrity and endothelial cell density during the life span of the mice using corneal fluorescein staining and in vivo confocal microscopy, respectively and compare their trends with that of the corneal thickness. Cornea thickness increases initially (1 month: 114.7 ± 3.0 μm, 6 months: 126.3 ± 1.6 μm), reaches a maximum (9 months: 129.3 ± 4.4 μm) and then reduces (12 months: 127 ± 2.9 μm, 13 months: 119.5 ± 7.6 μm, 14 months: 110.6 ± 10.6 μm), while the body size (weight) increases with age. We find that endothelial cell density reduces from 2 months old to 8 months old as the mice age and epithelial layer accumulates damages within this time frame. Finally, we compare murine corneal thickness with those of several other mammals including humans and show that corneal thickness has an allometric scaling with body size. Our results have relevance for organ size regulation, translational pharmacology, and veterinary medicine.
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