ArticleGut microbes2018
Inflammatory bactericidal lectin RegIIIβ: Friend or foe for the host?
Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Paneth Cells: Recent Updates on Elucidating Therapeutic Implications in Gastroenterological Disease Management.Current medicinal chemistry · 2025Pooled it
- Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure-activity relationships among anti-infective indoles.Gut microbes · 2026Article
- Infection strategies ofGut microbes reports · 2026Review
- RegIIIβ promotes Salmonella Typhimurium colonization of the gut in the early-stage gastrointestinal infection by enhancing flagella-driven locomotion.PLoS pathogens · 2025Article
- Understanding the intricate interactions between microbiota and host.World journal of experimental medicine · 2025Review
- Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience.Discovery immunology · 2025Article
- Lysate ofFrontiers in immunology · 2024Article
- Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice.Journal of advanced research · 2023Article
- Gut microecological regulation on bronchiolitis and asthma in children: A review.The clinical respiratory journal · 2023Review
- Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora.Chemico-biological interactions · 2022Review
- Vitamin A prevents lipopolysaccharide-induced injury on tight junctions in mice.Food science & nutrition · 2020Article
- Metabolic disturbance in hippocampus and liver of mice: A primary response to imidacloprid exposure.Scientific reports · 2020Article
- Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response.Psychopharmacology · 2019Review
- The Interplay betweenMicrobiology spectrum · 2019Article
- Gut Bacterial Metabolite Urolithin A (UA) Mitigates CaFrontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the inflamed gut, the bactericidal lectin RegIIIβ is massively produced by intestinal mucosa. RegIIIβ binds peptidoglycan and lipid A respectively, and thus can kill certain Gram-positive and Gram-negative bacteria, including the gut commensal microbiota and enteropathogenic bacteria. Considering the expression pattern and bactericidal activity, RegIIIβ is believed to be a host defense factor for protecting against the infection with enteropathogenic bacteria. However, it was poorly understood how RegIIIβ recognizes the target bacteria and kill them, and how RegIIIβ plays role(s) in infectious diarrhea. Therefore, our recent study has focused on RegIIIβ-target recognition, killing of Gram-negative bacteria, and host protective functions of RegIIIβ for infectious diarrhea inflicted by Salmonella Typhimurium. Here, we discuss novel insights into the protective role of RegIIIβ in infectious diarrhea, and propose avenues towards novel therapeutic interventions for Salmonella diarrhea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.