Evidence map›Paper›PMID 28985025›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Multidisciplinary approach to cardiac and pulmonary vascular disease risk assessment in liver transplantation: An evaluation of the evidence and consensus recommendations.

Lisa B VanWagner, Matthew E Harinstein, James R Runo, Christopher Darling, Marina Serper, Shelley Hall, Jon A Kobashigawa, Laura L Hammel

Open access · greenAbstract readEvaluation StudyConsensus Statement
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 150 citations in OpenAlex.

  1. Article
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  5. Review
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  7. The Cardiohepatic Axis in Cirrhosis.JACC. Basic to translational science · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
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  13. Impact of TAVR on patients with severe aortic stenosis and liver cirrhosis.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Lisa B VanWagnerDivision of Gastroenterology and Hepatology, Department of Medicine and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Matthew E HarinsteinHeart and Vascular Institute, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
James R RunoDivision of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Christopher DarlingDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Marina SerperDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Shelley HallDivision of Cardiology, Baylor University Medical Center, Dallas, TX, USA.
Jon A KobashigawaDivision of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Laura L HammelDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
University of Wisconsin–Madison · USBaylor University Medical Center · USCedars-Sinai Medical Center · USNorthwestern University · USUniversity of Pennsylvania · USUniversity of Pittsburgh Medical Center · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1M
Implementation science to improve cardiovascular outcomes among liver transplant recipientsK23HL136891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VANWAGNER, LISA B · 2017 to 2020
$757k
NCATS NIH HHS KL2 TR001424NHLBI NIH HHS K23 HL136891NHLBI NIH HHS L30 HL129581
6 · The paper itself

Abstract

Liver transplant (LT) candidates today are older, have greater medical severity of illness, and have more cardiovascular comorbidities than ever before. In addition, there are specific cardiovascular responses in cirrhosis that can be detrimental to the LT candidate. Cirrhotic cardiomyopathy, a condition characterized by increased cardiac output and a reduced ventricular response to stress, is present in up to 30% of patients with cirrhosis, thus challenging perioperative management. Current noninvasive tests that assess for subclinical coronary and myocardial disease have low sensitivity, and altered hemodynamics during the LT surgery can unmask latent cardiovascular disease either intraoperatively or in the immediate postoperative period. Therefore, this review, assembled by a group of multidisciplinary experts in the field and endorsed by the American Society of Transplantation Liver and Intestine and Thoracic and Critical Care Communities of Practice, provides a critical assessment of the diagnosis of cardiac and pulmonary vascular disease and interventions aimed at managing these conditions in LT candidates. Key points and practice-based recommendations for the diagnosis and management of cardiac and pulmonary vascular disease in this population are provided to offer guidance for clinicians and identify gaps in knowledge for future investigations.

Indexed as

Cardiovascular DiseasesHumansLiver TransplantationLung DiseasesPractice Guidelines as TopicRisk AssessmentVascular Resistancecardiovascular diseaseclinical research/practiceheart diseaseliver diseaseliver transplantation/hepatologyrisk assessment/risk stratification

Identifiers

PMID28985025
PMCPMC5840800
OpenAlexW2761266934

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.