Evidence map›Paper›PMID 28984909›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2018

Impact of maternal vaccination timing and influenza virus circulation on birth outcomes in rural Nepal.

Naoko Kozuki, Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq and 1 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01034254 (Field Trial of Maternal Influenza Immunization in Asia), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01034254 phase3completednot on this map

Field Trial of Maternal Influenza Immunization in Asia

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2010 to 2017Enrolled3,693ConditionsInfluenza HumanArmsinfluenza vaccine, saline placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Respiratory Virus Infection During Pregnancy: Does It Matter?The Journal of infectious diseases · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Naoko KozukiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Joanne KatzDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Janet A EnglundSeattle Children's Hospital and Research Foundation, University of Washington, Seattle, WA, USA.
Mark C SteinhoffDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Subarna K KhatryNepal Nutrition Intervention Project - Sarlahi, Kathmandu, Nepal.
Laxman ShresthaDepartment of Pediatrics and Child Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Jane KuypersMolecular Virology Laboratory, School of Medicine, University of Washington, Seattle, WA, USA.
Luke C MullanyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Helen Y ChuHarborview Medical Center, University of Washington, Seattle, WA, USA.
Steven C LeClerqDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
James M TielschDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Johns Hopkins University · USUniversity of Washington · USCincinnati Children's Hospital Medical Center · USMilken Institute · USSeattle Children's Hospital · USTribhuvan University · NP

Funding

Prospective Community-Based Study of RSV Risk Factors in Nepalese ChildrenK23AI103105 · NIAID · UNIVERSITY OF WASHINGTON · PI CHU, HELEN YING-HUI · 2013 to 2017
$897k
NIAID NIH HHS K23 AI103105
6 · The paper itself

Abstract

objectiveTo describe the effect of maternal vaccination on birth outcomes in rural Nepal, modified by timing of vaccination in pregnancy and influenza virus activity.

methodsA secondary analysis was conducted using data from two annual cohorts of a randomized controlled trial. A total of 3693 pregnant women from Sarlahi District were enrolled between April 25, 2011, and September 9, 2013. All participants were aged 15-40 years and received a trivalent inactivated influenza vaccine or placebo. The outcome measures included birth weight, pregnancy length, low birth weight (<2500 g), preterm birth, and small-for-gestational-age birth.

resultsData were available on birth weight for 2741 births and on pregnancy length for 3623 births. Maternal vaccination increased mean birthweight by 42 g (95% confidence interval [CI] 8-76). The magnitude of this increase varied by season but was greatest among pregnancies with high influenza virus circulation during the third trimester. Birth weight increased by 111 g (95% CI -51 to 273) when 75%-100% of a pregnancy's third trimester had high influenza virus circulation versus 38 g (95% CI -6 to 81) when 0%-25% of a pregnancy's third trimester had high influenza virus circulation. However, these results were nonsignificant.

conclusionSeasonal maternal influenza vaccination in rural Nepal increased birth weight; the magnitude appeared larger during periods of high influenza virus circulation. CLINICALTRIALS.GOV: NCT01034254.

Indexed as

Immunization ScheduleAdolescentAdultBirth WeightCohort StudiesFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeInfluenza, HumanInfluenza VaccinesNepalOrthomyxoviridaePregnancyPregnancy Trimester, ThirdInfluenza VaccinesInfluenzaLow birth weightNepalPregnancyPretermSmall for gestational ageVaccination

Identifiers

PMID28984909
PMCPMC5765513
OpenAlexW2763112209

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.