ArticleJournal of Alzheimer's disease : JAD2017
Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer's Disease.
Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Identifying risk factors of young-onset dementia and evaluating evidence hierarchy: a meta-analysis and umbrella review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Environmental and lifestyle risk factors for early-onset dementia: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Comorbidities and health-care use prior to early-onset Alzheimer's disease: A population-based case-control study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Connecting the Dots: Neurobiological Interplay Between Type 2 Diabetes and Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Assessing the risk of early-onset dementia within 5 years of cancer diagnosis Running Title: Early-onset dementia after cancer diagnosis.medRxiv : the preprint server for health sciences · 2026Article
- Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan.PLoS biology · 2025Article
- Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Risk Factors for Young-Onset Dementia in the UK Biobank.JAMA neurology · 2024Article
- Atypical clinical variants of Alzheimer's disease: are they really atypical?Frontiers in neuroscience · 2024Article
- Young-Onset Dementia and Neurodegenerative Disorders of the Young With an Emphasis on Clinical Manifestations.Cureus · 2022Review
- Regional associations of white matter hyperintensities and early cortical amyloid pathology.Brain communications · 2022Article
- Prevalence and incidence of young onset dementia and associations with comorbidities: A study of data from the French national health data system.PLoS medicine · 2021Article
- The Clinical Spectrum of Young Onset Dementia Points to Its Stochastic Origins.Journal of Alzheimer's disease reports · 2021Article
- Article
- Early-onset Alzheimer Disease and Its Variants.Continuum (Minneapolis, Minn.) · 2019Review
- The relationship between CSF biomarkers and cerebral metabolism in early-onset Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2019Article
- Pharmacogenetics of Vascular Risk Factors in Alzheimer's Disease.Journal of personalized medicine · 2018Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeterminants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation.
objectiveThe objective of this study was to assess the putative association between VRFs and EOAD.
methodsWe studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007). Demographic data, VRFs, comorbidities, treatments, and APOE genotypes were compared in multivariable logistic regression analyses.
resultsWe studied 102 participants with dementia (mean±standard deviation age: 59.5±3.8; women: 59.8%) and 306 controls. Compared with controls, EOAD participants had spent less time in formal education (9.9±2.9 versus 11.7±3.8 y; p < 0.0001), were less likely to be regular alcohol consumers (p < 0.0001), had a lower body mass index (-2 kg/m2; p < 0.0004), and a lower mean systolic blood pressure (-6.2 mmHg; p = 0.0036). The prevalence of APOE ɛ4 allele was higher in participants with dementia than in controls (50% versus 29.4%; p = 0.0002), as was the prevalence of depression (48% versus 32%; p < 0.001). Similar results were observed in multivariable analysis. Compared with EOAD participants lacking VRFs, EOAD participants with at least one VRF had a higher prevalence of depression (29.6% versus 53.3%, respectively; p = 0.03).
conclusionThe prevalence of VRFs is not elevated in EOAD patients (in contrast to older AD patients). Extensive genetic testing should be considered more frequently in the context of EOAD.
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