Evidence map›Paper›PMID 28984588›Full record

ArticleJournal of Alzheimer's disease : JAD2017

Secular Trends in the Incidence of Dementia in a Multi-Ethnic Community.

James M Noble, Nicole Schupf, Jennifer J Manly, Howard Andrews, Ming-Xin Tang, Richard Mayeux

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Review
  7. Article
  8. Association of Race and Income with Incident Diagnosis of Alzheimer's Disease and Related Dementias among Black and White Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023
    Article
  9. Review
  10. Article
  11. Vascular Cognitive Impairment (VCI).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  12. Article
  13. A New Look at Cohort Trend and Underlying Mechanisms in Cognitive Functioning.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Medicaid Contributes Substantial Costs to Dementia Care in an Ethnically Diverse Community.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James M NobleTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Jennifer J ManlyTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Howard AndrewsDepartment of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
Ming-Xin TangG.H. Sergievsky Center, Columbia University, New York, NY, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Columbia University · USColumbia University Irving Medical Center · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MAYEUX, RICHARD P · 1989 to 2008
$21.7M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
NCATS NIH HHS UL1 TR001873NIA NIH HHS P01 AG007232NIA NIH HHS R01 AG037212NIA NIH HHS RF1 AG054023
6 · The paper itself

Abstract

backgroundDetermination of secular trends in cognitive aging is important for prioritization of resources, services, and research in aging populations. Prior studies have identified declining dementia incidence associated with changes in cardiovascular risk factors and increased educational attainment. However, few studies have examined these factors in multi-ethnic cohorts.

objectiveTo identify secular trends in the incidence rate of dementia in an elderly population.

methodsParticipants in this study were drawn from the Washington Heights-Inwood Columbia Aging Project, a multi-ethnic cohort study of northern Manhattan residents aged 65 years and older. Cox proportional hazards models were used to examine differences in the incidence of dementia in cohorts recruited in 1992 and 1999, with age at dementia or age at last follow-up visit as the "time-to-event" variable.

resultsOverall, there was a 41% reduction in the hazard ratio for dementia among participants in the 1999 cohort compared with those in the 1992 cohort, adjusting for age, sex, race, and baseline memory complaints (HR = 0.59). The reduction in incidence was greatest among non-Hispanic Whites and African-Americans and lowest among Hispanic participants (HRs = 0.60, 0.52 and 0.64, respectively), and was associated with increases in level of educational attainment, especially among African-Americans. Reduction in incidence of dementia was also greater among persons 75 years or older than among younger participants (HR = 0.52 versus HR = 0.69).

conclusionsOur results support previous findings that secular trends in dementia incidence are changing, including in aging minority populations.

Indexed as

Residence CharacteristicsSecularismAgedAged, 80 and overBlack or African AmericanCohort StudiesDementiaFemaleHispanic or LatinoHumansIncidenceMaleNeuropsychological TestsProportional Hazards ModelsPsychiatric Status Rating ScalesRisk FactorsCohortsdementiaincidencerace/ethnicitysecular trends

Identifiers

PMID28984588
PMCPMC6084436
OpenAlexW2761329235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.