Evidence map›Paper›PMID 28984235›Full record

ReviewMicrobiology spectrum2017

Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology.

Melinda A Engevik, James Versalovic

Abstract readReview
In one paragraph

Review in Microbiology spectrum, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
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  14. Article
  15. New Insights into Boron Essentiality in Humans and Animals.International journal of molecular sciences · 2022
    Review
  16. Article
  17. iScience · 2022
    Article
  18. Review
  19. Frontiers in physiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melinda A EngevikDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030 and Department of Pathology, Texas Children's Hospital, Houston, TX 77030.
James VersalovicDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030 and Department of Pathology, Texas Children's Hospital, Houston, TX 77030.

Funding

Gut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8M
Modulation of NF-kB Signaling by ImmunoprobioticsR01AT004326 · NCCIH · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2008 to 2011
$1.8M
Intestinal Lactobacillus and Mucosal ImmunomodulationR01DK065075 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2007 to 2010
$1.3M
NCCIH NIH HHS R01 AT004326NCI NIH HHS U01 CA170930NIDDK NIH HHS R01 DK065075
6 · The paper itself

Abstract

Commensal and beneficial microbes secrete myriad products which target the mammalian host and other microbes. These secreted substances aid in bacterial niche development, and select compounds beneficially modulate the host and promote health. Microbes produce unique compounds which can serve as signaling factors to the host, such as biogenic amine neuromodulators, or quorum-sensing molecules to facilitate inter-bacterial communication. Bacterial metabolites can also participate in functional enhancement of host metabolic capabilities, immunoregulation, and improvement of intestinal barrier function. Secreted products such as lactic acid, hydrogen peroxide, bacteriocins, and bacteriocin-like substances can also target the microbiome. Microbes differ greatly in their metabolic potential and subsequent host effects. As a result, knowledge about microbial metabolites will facilitate selection of next-generation probiotics and therapeutic compounds derived from the mammalian microbiome. In this article we describe prominent examples of microbial metabolites and their effects on microbial communities and the mammalian host.

Indexed as

MetabolomeAnimalsAnti-Infective AgentsBacteriaBacteriocinsExtracellular VesiclesFatty AcidsHumansHydrogen PeroxideLactic AcidMicrobial InteractionsMicrobiotaNeurotransmitter AgentsPolyaminesProbioticsSerine EndopeptidasesAnti-Infective AgentsBacteriocinsFatty AcidsHydrogen PeroxideLactic AcidlactocepinNeurotransmitter AgentsPolyaminesSerine EndopeptidasesSerpinsVitamins

Identifiers

PMID28984235
PMCPMC5873327

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.