Trial reportMultiple sclerosis (Houndmills, Basingstoke, England)2018
Longer term effectiveness of inpatient multidisciplinary rehabilitation on health-related quality of life in MS patients: a pragmatic randomized controlled trial - The Danish MS Hospitals Rehabilitation Study.
Trial report in Multiple sclerosis (Houndmills, Basingstoke, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07202195 (Home-Based Neuromodulation Suits for Reducing Spasticity and Ataxia in Multiple Sclerosis), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home-Based Neuromodulation Suits for Reducing Spasticity and Ataxia in Multiple Sclerosis: A Multi-center RCT
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Use of pragmatic randomized trials in multiple sclerosis: A systematic overview.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Pooled it
- Interprofessional collaboration and patient-reported outcomes in inpatient care: a systematic review.Systematic reviews · 2022Pooled it
- Systematic review of pragmatic randomised control trials assessing the effectiveness of professional pharmacy services in community pharmacies.BMC health services research · 2021Pooled it
- Can inpatient multidisciplinary rehabilitation improve health-related quality of life in MS patients on the long term - The Danish MS Hospitals Rehabilitation Study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Trial
- Trial
- Hospital-to-Home Neurological Transition Care: A Scoping Review Across Selected Chronic Neurological Disorders.Medical sciences (Basel, Switzerland) · 2026Article
- Changes in health-related quality of life during outpatient rehabilitation: a prospective observational cohort study in four patient groups.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Observational
- Shedding Light on the Black Box of Rehabilitation: Differential Short- and Long-Term Effects of Multidisciplinary Multiple Sclerosis Rehabilitation.International journal of MS care · 2024Article
- A general theory of rehabilitation: Rehabilitation catalyses and assists adaptation to illness.Clinical rehabilitation · 2024Article
- Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis.Journal of biological engineering · 2022Review
- Aggressive multiple sclerosis (2): Treatment.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- What is rehabilitation? An empirical investigation leading to an evidence-based description.Clinical rehabilitation · 2020Article
- Content and Delivery of Physical Therapy in Multiple Sclerosis across Europe: A Survey.International journal of environmental research and public health · 2020Article
- Tablet App Based Dexterity Training in Multiple Sclerosis (TAD-MS): Research Protocol of a Randomized Controlled Trial.Frontiers in neurology · 2019Article
- Cost-efficiency of specialist inpatient rehabilitation for adults with multiple sclerosis: A multicentre prospective cohort analysis of the UK Rehabilitation Outcomes Collaborative national clinical dataset for rehabilitation centres in England.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Personalised inpatient multidisciplinary rehabilitation elicits clinically relevant improvements in physical function in patients with multiple sclerosis - The Danish MS Hospitals Rehabilitation Study.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Predictors of hospital-based multidisciplinary rehabilitation effects in persons with multiple sclerosis: a large-scale, single-centre study.Multiple sclerosis journal - experimental, translational and clinicalArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is insufficient evidence to support the effectiveness of multidisciplinary rehabilitation on the health-related quality of life (HRQoL) of MS patients.
objectivesTo evaluate the longer term effectiveness of inpatient multidisciplinary rehabilitation on the HRQoL of MS patients.
methodsThe study was a two-hospital, pragmatic, randomized controlled trial with a 6-month follow-up. Patients aged 18-65 years with MS and Expanded Disability Status Scale scores ≤7.5 were randomly assigned (1:1) to 4 weeks of inpatient multidisciplinary rehabilitation (20 days of scheduled rehabilitation) or 6 months on a wait list. The outcome measures were Functional Assessment in Multiple Sclerosis (FAMS), Multiple Sclerosis Impact Scale-29 (MSIS-29), EQ-5D-5L and 15D.
resultsWe randomized 213 patients to the wait-list control group and 214 patients to the treatment group. Trends in favour of the treatment group were observed across all measures. However, the difference was significant in only two of the six measures. The treatment effect was -2.7 (95% CI: -5.6 to (-0.1)), p = 0.046) for the MSIS-29 Psychological and 0.017 (95% CI: 0.005-0.030, p = 0.008) for the 15D. FAMS, which we used to calculate the sample size, was not significant.
conclusionThe results indicated that inpatient multidisciplinary rehabilitation is effective in improving the HRQoL of MS patients after 6 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.