Evidence map›Paper›PMID 28984072›Full record

Observational studyPediatric transplantation2017

Recruiting a representative sample in adherence research-The MALT multisite prospective cohort study experience.

Eyal Shemesh, Jeffrey Mitchell, Katie Neighbors, Susan Feist, Andre Hawkins, Amanda Brown, Yin Wanrong, Ravinder Anand, Margaret L Stuber, Rachel A Annunziato

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A remote intervention to improve medication nonadherence guided by a marker of risk derived from the electronic health records of adolescent transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eyal ShemeshIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-2508-3423
Jeffrey MitchellThe Emmes Corporation, Rockville, MD, USA.
Katie NeighborsAnn & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Susan FeistMattel Children's Hospital at UCLA, Los Angeles, CA, USA.
Andre HawkinsCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Amanda BrownHillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Yin WanrongThe Emmes Corporation, Rockville, MD, USA.
Ravinder AnandThe Emmes Corporation, Rockville, MD, USA.
Margaret L StuberDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Rachel A AnnunziatoIcahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Medication Adherence in Children Who Had a Liver Transplant (MALT)R01DK080740 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHEMESH, EYAL · 2009 to 2014
$3.3M
NIDDK NIH HHS R01 DK080740
6 · The paper itself

Abstract

Medication adherence is an important determinant of transplant outcomes. Attempts to investigate adherence are frequently undermined by selection bias: It is very hard to recruit and retain non-adherent patients in research efforts. This manuscript presents recruitment strategies and results from the MALT (Medication Adherence in children who had a Liver Transplant) multisite prospective cohort study. MALT sites recruited 400 pediatric liver transplant patients who agreed to be followed for 2 years. The primary purpose was to determine whether a marker of adherence, the Medication Level Variability Index (MLVI), predicts rejection outcomes. The present manuscript describes methods used in MALT to ensure that a representative sample was recruited, and presents detailed recruitment results. MALT sites were able to recruit a nationally representative sample, as determined by a comparison between the MALT cohort and a national sample of transplant recipients. Strategies that helped ensure that the sample was representative included monitoring of the outcome measure in comparison with a national sample, drastically limiting patient burden, and specific recruitment methods. We discuss the importance of a representative sample in adherence research and recommend that future efforts to study adherence pay special attention to sample characteristics.

Indexed as

Drug MonitoringLiver TransplantationAdolescentChildChild, PreschoolDecision Support TechniquesFemaleFollow-Up StudiesGraft RejectionHumansImmunosuppressive AgentsInfantMalePatient SelectionProspective StudiesSelection BiasImmunosuppressive Agentsadherencepediatricrecruitmenttransplant

Identifiers

PMID28984072
PMCPMC5698095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.