ReviewThe Journal of physiology2018
The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo.
Review in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression.Comprehensive Physiology · 2026Article
- Cord blood metabolomics: a window into future heart health.Pediatric research · 2026Article
- Fetal growth and congenital heart disease at high altitude.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Development and sex affect respiratory responses to temperature and dissolved oxygen in the air-breathing fishes Betta splendens and Trichopodus trichopterus.Fish physiology and biochemistry · 2025Article
- Developmental plasticity of the cardiovascular system in oviparous vertebrates: effects of chronic hypoxia and interactive stressors in the context of climate change.The Journal of experimental biology · 2024Review
- Electrical remodeling of atrioventricular junction: a study on retrogradely perfused chick embryonic heart.American journal of physiology. Heart and circulatory physiology · 2024Article
- Effects of hypoxia on uteroplacental and fetoplacental vascular function during pregnancy.Frontiers in physiology · 2024Review
- Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy.Antioxidants (Basel, Switzerland) · 2022Review
- Breath of Life: Heart Disease Link to Developmental Hypoxia.Circulation · 2021Article
- Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction.Science advances · 2020Article
- Hypertension Programmed in Adult Hens by Isolated Effects of Developmental Hypoxia In Ovo.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction†.Biology of reproduction · 2020Article
- Stimulation of the ACE2/Ang-(1-7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles ( Chelydra serpentina).Proceedings. Biological sciences · 2019Article
- Prenatal hypoxia impairs cardiac mitochondrial and ventricular function in guinea pig offspring in a sex-related manner.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Advances in cellular and integrative control of oxygen and carbon dioxide homeostasis.The Journal of physiology · 2018Article
- Isolating the direct effects of adverse developmental conditions on in vivo cardiovascular function at adulthood: the avian model.Journal of developmental origins of health and disease · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
It is now established that adverse conditions during pregnancy can trigger a fetal origin of cardiovascular dysfunction and/or increase the risk of heart disease in later life. Suboptimal environmental conditions during early life that may promote the development of cardiovascular dysfunction in the offspring include alterations in fetal oxygenation and nutrition as well as fetal exposure to stress hormones, such as glucocorticoids. There has been growing interest in identifying the partial contributions of each of these stressors to programming of cardiovascular dysfunction. However, in humans and in many animal models this is difficult, as the challenges cannot be disentangled. By using the chicken embryo as an animal model, science has been able to circumvent a number of problems. In contrast to mammals, in the chicken embryo the effects on the developing cardiovascular system of changes in oxygenation, nutrition or stress hormones can be isolated and determined directly, independent of changes in the maternal or placental physiology. In this review, we summarise studies that have exploited the chicken embryo model to determine the effects on prenatal growth, cardiovascular development and pituitary-adrenal function of isolated chronic developmental hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.