ArticleEvolution; international journal of organic evolution2017
The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions.
Article in Evolution; international journal of organic evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Microbial Resource Regimes Shape Early Survival, Growth, and Reproductive Morphology in a Phally Polymorphic Terrestrial Gastropod.Microbial ecology · 2026Article
- Epigenetic Phase Variation in Bacterial Adaptation to Environmental Stress: A Narrative Review.Current microbiology · 2026Review
- Functionality versus Adaptation: Insights from Transcriptional Adaptation.Journal of molecular evolution · 2026Review
- Leaffooted bugs enrich local soil with their horizontally acquired symbiont.Frontiers in microbiology · 2026Article
- Codon bias variation in Staphylococcus aureus.PloS one · 2026Article
- Stochastic phenotypic switching arises in response to directional selection in experimentally evolved multicellular yeast.Communications biology · 2025Article
- The Role of Phenotypic Plasticity and Within-Environment Trait Variability in the Assembly of the Nectar Microbiome and Plant-Microbe-Animal Interactions.Ecology and evolution · 2025Review
- 100+ years of phase variation: the premier bacterial bet-hedging phenomenon.Microbiology (Reading, England) · 2025Review
- Effects of periodic bottlenecks on the dynamics of adaptive evolution in microbial populations.Microbiology (Reading, England) · 2024Article
- Article
- A Selective Bottleneck During Host Entry Drives the Evolution of New Legume Symbionts.Molecular biology and evolution · 2023Article
- Article
- Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation.Molecular biology and evolution · 2022Article
- Single cell variability of CRISPR-Cas interference and adaptation.Molecular systems biology · 2022Article
- Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance.Nature ecology & evolution · 2021Article
- Refined Quantification of Infection Bottlenecks and Pathogen Dissemination with STAMPR.mSystems · 2021Article
- Quantification ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Common Adaptive Strategies Underlie Within-Host Evolution of Bacterial Pathogens.Molecular biology and evolution · 2021Article
- Yeast Fermentate-Mediated Reduction ofFrontiers in microbiology · 2021Article
- Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.PLoS computational biology · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Microbial pathogens and viruses can often maintain sufficient population diversity to evade a wide range of host immune responses. However, when populations experience bottlenecks, as occurs frequently during initiation of new infections, pathogens require specialized mechanisms to regenerate diversity. We address the evolution of such mechanisms, known as stochastic phenotype switches, which are prevalent in pathogenic bacteria. We analyze a model of pathogen diversification in a changing host environment that accounts for selective bottlenecks, wherein different phenotypes have distinct transmission probabilities between hosts. We show that under stringent bottlenecks, such that only one phenotype can initiate new infections, there exists a threshold stochastic switching rate below which all pathogen lineages go extinct, and above which survival is a near certainty. We determine how quickly stochastic switching rates can evolve by computing a fitness landscape for the evolutionary dynamics of switching rates, and analyzing its dependence on both the stringency of bottlenecks and the duration of within-host growth periods. We show that increasing the stringency of bottlenecks or decreasing the period of growth results in faster adaptation of switching rates. Our model provides strong theoretical evidence that bottlenecks play a critical role in accelerating the evolutionary dynamics of pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.