Evidence map›Paper›PMID 28983745›Full record

ArticleAnnals of biomedical engineering2018

Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer.

Qi Shao, Feng Liu, Connie Chung, Kianna Elahi-Gedwillo, Paolo P Provenzano, Bruce Forsyth, John C Bischof

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qi ShaoDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-8190-1067
Feng LiuDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE, Minneapolis, MN, 55455, USA.
Connie ChungDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE, Minneapolis, MN, 55455, USA.
Kianna Elahi-GedwilloDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Paolo P ProvenzanoInstitute for Engineering in Medicine, University of Minnesota, Minneapolis, MN, USA.
Bruce ForsythBoston Scientific Corporation, Maple Grove, MN, USA.
John C BischofDepartment of Mechanical Engineering, University of Minnesota, 111 Church St. SE, Minneapolis, MN, 55455, USA. bischof@umn.edu.

Funding

Project 2: Cell Migration in Mechanically Complex MicroenvironmentsU54CA210190 · NCI · UNIVERSITY OF MINNESOTA · PI ODDE, DAVID J. · 2016 to 2020
$10.0M
Stellate cells and their progenitor precursors in pancreas cancer progressionR01CA181385 · NCI · UNIVERSITY OF MINNESOTA · PI PROVENZANO, PAOLO · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA181385NCI NIH HHS U54 CA210190Office of Extramural Research, National Institutes of Health R01CA181385Office of Extramural Research, National Institutes of Health U54CA210190University of Minnesota CarlUniversity of Minnesota Doctoral Dissertation FellowshipUniversity of Minnesota IEM Cancer Animal CoreUniversity of Minnesota Janet Kuhrmeyer Chair
6 · The paper itself

Abstract

Irreversible electroporation (IRE) can be used to treat cancer by electrical pulses, with advantages over traditional thermal approaches. Here we assess for the first time the IRE response of pancreatic cancer, one of the deadliest forms of cancer, both in vitro and in vivo. We demonstrate that both established and primary cancer cell lines can be destroyed by IRE, but with differential susceptibility and thresholds. We further demonstrate in vitro that viability for a given IRE dose can vary with the local chemistry as outcomes were shown to depend on suspending medium and reduction of glucose in the media significantly improved IRE destruction. Data here also demonstrate that repeated IRE treatments can lead to adaptive resistance in pancreatic carcinoma cells thereby reducing subsequent treatment efficacy. In addition, we demonstrate that physical enhancement of IRE, by re-arranging the pulse sequences without increasing the electrical energy delivered, achieve reduced viability in vitro and decreased tumor growth in an in vivo xenograft model. Together, these results show that IRE can destroy pancreatic cancer in vitro and in vivo, that there are both chemical and physical enhancements that can improve tumor destruction, and that one should guard against adaptive resistance when performing repeated treatments.

Indexed as

ElectroporationAdaptation, PhysiologicalAnimalsCell Line, TumorCell SurvivalGlucoseHumansMaleMice, NudePancreatic NeoplasmsTumor BurdenGlucoseAdaptationCancer treatmentEnhancementGlucoseIn vitroIn vivoIrreversible electroporationPancreatic cancerResistance

Identifiers

PMID28983745
PMCPMC6057480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.