Evidence map›Paper›PMID 28983743›Full record

ArticleMolecular imaging and biology2018

PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [

Chongzhao Ran, Daniel S Albrecht, Miriam A Bredella, Jing Yang, Jian Yang, Steven H Liang, Aaron M Cypess, Marco L Loggia, Nazem Atassi, Anna Moore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021
    Review
  10. Comparative [Adipocyte · 2020
    Article
  11. PHOSPHO1 puts the breaks on thermogenesis in brown adipocytes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Brown Adipose Tissue Energy Metabolism in Humans.Frontiers in endocrinology · 2018
    Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chongzhao RanMolecular Imaging Laboratory, Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA. cran@nmr.mgh.harvard.edu.
Daniel S AlbrechtAthinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.
Miriam A BredellaDivision of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Jing YangMolecular Imaging Laboratory, Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.
Jian YangMolecular Imaging Laboratory, Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Aaron M CypessDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Marco L LoggiaAthinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.
Nazem AtassiNeurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Anna MooreMolecular Imaging Laboratory, Athinoula. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.
Athinoula A. Martinos Center for Biomedical Imaging · USHarvard University · USMassachusetts General Hospital · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Physiological Responses to Activation of Human Brown Adipose TissueZIADK075116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$6.1M
The Molecular, Cellular, and Genetic characterization of Human Adipose Tissue and its Role in MetabolismZIADK075112 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$2.8M
Mechanisms Underlying Adipose Tissue ThermogenesisZIADK075115 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$1.8M
Imaging brown adipose tissue and monitoring browningR56DK108813 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2016 to 2017
$567k
Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA DK075112Intramural NIH HHS ZIA DK075115Intramural NIH HHS ZIA DK075116NIDDK NIH HHS R56 DK108813NIDDK NIH HHS R56DK108813
6 · The paper itself

Abstract

purposeBrown adipose tissue (BAT) in adult humans has been recently rediscovered and intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes (T2D). However, reliable assessment of BAT mass in vivo represents a considerable challenge. The purpose of this investigation is to demonstrate for the first time that human BAT depots can be imaged with a translocator protein (TSPO)-specific positron emission tomography (PET) tracer [ PROCEDURES: In this retrospective analysis, we analyzed the images of three healthy volunteers who underwent PET/magnetic resonance (MR) imaging after injection of 14 m Ci of [

results[

conclusionsIn this brief article, we provide the first evidence suggesting that [

Indexed as

Positron-Emission TomographyAdipose Tissue, BrownAdultFemaleHealthy VolunteersHumansMagnetic Resonance ImagingMalePyrimidinesReceptors, GABA(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinaminePyrimidinesReceptors, GABATSPO protein, humanBrown adipose tissueC-11 PBR28Metabolic diseaseThermoneutral conditionsTSPO

Identifiers

PMID28983743
PMCPMC6394407
OpenAlexW2763631340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.