ArticleBiomechanics and modeling in mechanobiology2018
Multi-resolution geometric modeling of the mitral heart valve leaflets.
Article in Biomechanics and modeling in mechanobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Computational simulation model of transcatheter edge-to-edge mitral valve repair: a proof-of-concept study.European heart journal. Cardiovascular Imaging · 2024Article
- Semi-Automated Construction of Patient-Specific Aortic Valves from Computed Tomography Images.Annals of biomedical engineering · 2023Article
- In vivo assessment of mitral valve leaflet remodelling following myocardial infarction.Scientific reports · 2022Article
- Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains.Annals of biomedical engineering · 2021Article
- Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves.Computer methods in applied mechanics and engineering · 2021Article
- Geometric description for the anatomy of the mitral valve: A review.Journal of anatomy · 2020Review
- Mitral valve leaflet response to ischaemic mitral regurgitation: from gene expression to tissue remodelling.Journal of the Royal Society, Interface · 2020Article
- On the simulation of mitral valve function in health, disease, and treatment.Journal of biomechanical engineering · 2019Article
- Development of a Functionally Equivalent Model of the Mitral Valve Chordae Tendineae Through Topology Optimization.Annals of biomedical engineering · 2019Article
- Extraction of open-state mitral valve geometry from CT volumes.International journal of computer assisted radiology and surgery · 2018Article
- The Three-Dimensional Microenvironment of the Mitral Valve: Insights into the Effects of Physiological Loads.Cellular and molecular bioengineering · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
An essential element of cardiac function, the mitral valve (MV) ensures proper directional blood flow between the left heart chambers. Over the past two decades, computational simulations have made marked advancements toward providing powerful predictive tools to better understand valvular function and improve treatments for MV disease. However, challenges remain in the development of robust means for the quantification and representation of MV leaflet geometry. In this study, we present a novel modeling pipeline to quantitatively characterize and represent MV leaflet surface geometry. Our methodology utilized a two-part additive decomposition of the MV geometric features to decouple the macro-level general leaflet shape descriptors from the leaflet fine-scale features. First, the general shapes of five ovine MV leaflets were modeled using superquadric surfaces. Second, the finer-scale geometric details were captured, quantified, and reconstructed via a 2D Fourier analysis with an additional sparsity constraint. This spectral approach allowed us to easily control the level of geometric details in the reconstructed geometry. The results revealed that our methodology provided a robust and accurate approach to develop MV-specific models with an adjustable level of spatial resolution and geometric detail. Such fully customizable models provide the necessary means to perform computational simulations of the MV at a range of geometric accuracies in order to identify the level of complexity required to achieve predictive MV simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.